{"id":11976,"date":"2023-01-05T03:42:49","date_gmt":"2023-01-04T19:42:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11976"},"modified":"2023-01-05T03:42:49","modified_gmt":"2023-01-04T19:42:49","slug":"elguero-jose-et-al-published-their-research-in-compt-rend-in-1965-cas-934-48-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11976","title":{"rendered":"Elguero, Jose et al. published their research in Compt. Rend. in 1965 | CAS: 934-48-5"},"content":{"rendered":"<p>Investigation of azoles. N-Carbamoylpyrazoles was written by Elguero, Jose;Jacquier, Robert. And the article was included in Compt. Rend. in 1965.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">Category: pyrazoles-derivatives<\/a> This article mentions the following:<\/p>\n<p>A series of 3- and 5-methyl-1-carbamoylpyrazoles, obtained from H<sub>2<\/sub>NCONHNH<sub>2<\/sub>.HCl with various acetoacetaldehyde derivatives, were identified by their N.M.R. and uv spectra. Several symmetrically substituted N-carbamoylpyrazoles were also studied. 1-Carbamoylpyrazole (I), m. 140-1\u00b0, with Br in CHCl<sub>3<\/sub> gave the 4-Br derivative of I, m. 187-9\u00b0 (EtOH). 3,5-Dimethyl-1-carbamoylpyrazole, m. 113.5\u00b0, gave similarly the 4-Br derivative, m. 152-3\u00b0. The mixture, m. 98-9\u00b0, obtained from H<sub>2<\/sub>NCONHNH<sub>2<\/sub>.HCl with (MeO)<sub>2<\/sub>CHCH<sub>2<\/sub>Ac, contained, according to its N.M.R. spectrum, 40% 3-Me derivative of I and 60% 5-Me derivative of I, and according to its uv spectrum 43 and 57%, resp. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">Category: pyrazoles-derivatives<\/a>).<\/p>\n<p>3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11976","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Elguero, Jose et al. published their research in Compt. 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