{"id":11974,"date":"2023-01-05T03:42:49","date_gmt":"2023-01-04T19:42:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11974"},"modified":"2023-01-05T03:42:49","modified_gmt":"2023-01-04T19:42:49","slug":"dorn-helmut-et-al-published-their-research-in-chemische-berichte-in-1966-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11974","title":{"rendered":"Dorn, Helmut et al. published their research in Chemische Berichte in 1966 | CAS: 3528-58-3"},"content":{"rendered":"<p>Redox cleavage of sulfonamides. V. Structure of the bis-(arylsulfonyl) derivatives of 5-amino-1-methylpyrazole was written by Dorn, Helmut;Hilgetag, Guenter;Zubek, Alfred. And the article was included in Chemische Berichte in 1966.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a> This article mentions the following:<\/p>\n<p>Bis(arylsulfonyl) derivatives of 5-amino-1-methylpyrazole formed from 5-amino-1-methylpyrazole (I) and the 5-SO<sub>2<\/sub>NH<sub>2<\/sub> analog of I in C<sub>5<\/sub>H<sub>5<\/sub>N were shown by spectroscopic and chem. evidence to carry the 2 sulfonyl groups on the exocyclic N atom. II (Ar = Ph or p-ClC<sub>6<\/sub>H<sub>4<\/sub>) (0.004 mole) in 16 cc. dry C<sub>5<\/sub>H<sub>5<\/sub>N shaken 48 hrs. at room temperature with 0.0043 mole Ar&#8217;SO<sub>2<\/sub>Cl (Ar&#8217; = p-ClC<sub>6<\/sub>H<sub>4<\/sub> or p-MeC<sub>6<\/sub>H<sub>4<\/sub>) and poured onto ice and 80 cc. 2N HCl gave the following III (Ar, Ar&#8217;, % yield, and m.p. given): Ph, p-ClC<sub>6<\/sub>H<sub>4<\/sub>, (IV), 81.5, 128-9\u00b0; Ph, p-MeC<sub>6<\/sub>H<sub>4<\/sub> (V), 85.0, 116-17\u00b0; p-ClC<sub>6<\/sub>H<sub>4<\/sub>, p-MeC<sub>6<\/sub>H<sub>4<\/sub>, (VI), 74.2, 171-2\u00b0. The same compounds were also prepared in a similar manner from the II (Ar = p-ClC<sub>6<\/sub>H<sub>4<\/sub> or p-MeC<sub>6<\/sub>H<sub>4<\/sub>) with the Ar&#8217;SO<sub>2<\/sub>Cl (Ar&#8217; = Ph or p-ClC<sub>5<\/sub>H<sub>4<\/sub>) (% given): IV 51.2, V 62.4, VI 65.8. The uv spectra of 5-(p-toluenesulfonamino)-1-methylpyrazole, V, and VI are recorded. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11974","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dorn, Helmut et al. published their research in Chemische Berichte in 1966 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Redox cleavage of sulfonamides. V. Structure of the bis-(arylsulfonyl) derivatives of 5-amino-1-methylpyrazole was written by Dorn, Helmut;Hilgetag, Guenter;Zubek, Alfred. 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