{"id":11958,"date":"2023-01-04T08:13:19","date_gmt":"2023-01-04T00:13:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11958"},"modified":"2023-01-04T08:13:19","modified_gmt":"2023-01-04T00:13:19","slug":"kim-kundo-et-al-published-their-research-in-journal-of-organic-chemistry-in-2022-cas-73387-46-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11958","title":{"rendered":"Kim, Kundo et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 73387-46-9"},"content":{"rendered":"<p>Copper-Catalyzed Hydroamination of Oxa- and Azabenzonorbornadienes with Pyrazoles was written by Kim, Kundo;Lee, Yunmi. And the article was included in Journal of Organic Chemistry in 2022.<a href=\"https:\/\/www.ambeed.com\/products\/73387-46-9.html\">Application In Synthesis of 3-(4-Bromophenyl)-1H-pyrazole<\/a> This article mentions the following:<\/p>\n<p>An efficient and highly chemo- and stereoselective copper-catalyzed hydroamination of oxa- and azabenzonorbornadienes with various pyrazole derivatives is described. This catalytic process is promoted by the presence of N-heterocyclic carbene ligands and KOt-Bu under mild and simple reaction conditions, and allows for the direct synthesis of new and versatile functionalized oxa(aza)benzonorbornyl pyrazoles <strong>I<\/strong> (R = H, 6,7-(OMe)<sub>2<\/sub>, 6,7-(Br)<sub>2<\/sub>, etc; X = O, N(Boc), N(Ac), etc.; R<sup>1<\/sup> = H, 4-Me, 4-Cl, etc.) starting from readily available oxa(aza)bicyclic alkenes. The synthetic utility of this method was demonstrated by the transformation of the obtained products into pyrazolyl-substituted naphthalenes. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9<a href=\"https:\/\/www.ambeed.com\/products\/73387-46-9.html\">Application In Synthesis of 3-(4-Bromophenyl)-1H-pyrazole<\/a>).<\/p>\n<p>3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/73387-46-9.html\">Application In Synthesis of 3-(4-Bromophenyl)-1H-pyrazole<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/73387-46-9.html\">Application In Synthesis of 3-(4-Bromophenyl)-1H-pyrazole<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[129],"class_list":["post-11958","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kim, Kundo et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 73387-46-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Copper-Catalyzed Hydroamination of Oxa- and Azabenzonorbornadienes with Pyrazoles was written by Kim, Kundo;Lee, Yunmi. 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