{"id":11957,"date":"2023-01-04T08:13:19","date_gmt":"2023-01-04T00:13:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11957"},"modified":"2023-01-04T08:13:19","modified_gmt":"2023-01-04T00:13:19","slug":"khachatryan-d-s-et-al-published-their-research-in-russian-chemical-bulletin-in-2017-cas-15953-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11957","title":{"rendered":"Khachatryan, D. S. et al. published their research in Russian Chemical Bulletin in 2017 | CAS: 15953-73-8"},"content":{"rendered":"<p>Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones was written by Khachatryan, D. S.;Belus, S. K.;Misyurin, V. A.;Baryshnikova, M. A.;Kolotaev, A. V.;Matevosyan, K. R.. And the article was included in Russian Chemical Bulletin in 2017.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">HPLC of Formula: 15953-73-8<\/a> This article mentions the following:<\/p>\n<p>Herein, the modified preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives by the reaction of new and com. available aromatic aldehydes with anthranilic acid amides has been described. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">HPLC of Formula: 15953-73-8<\/a>).<\/p>\n<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">HPLC of Formula: 15953-73-8<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">HPLC of Formula: 15953-73-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11957","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Khachatryan, D. S. et al. published their research in Russian Chemical Bulletin in 2017 | CAS: 15953-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones was written by Khachatryan, D. S.;Belus, S. K.;Misyurin, V. 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