{"id":11951,"date":"2023-01-04T08:13:19","date_gmt":"2023-01-04T00:13:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11951"},"modified":"2023-01-04T08:13:19","modified_gmt":"2023-01-04T00:13:19","slug":"kushwah-shruti-et-al-published-their-research-in-international-journal-of-pharmaceutical-research-and-bio-science-in-2012-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11951","title":{"rendered":"Kushwah, Shruti et al. published their research in International Journal of Pharmaceutical Research and Bio-Science in 2012 | CAS: 3528-58-3"},"content":{"rendered":"<p>Synthesis and pharmacological screening of pyrazolopyridine compounds as anxiolytics was written by Kushwah, Shruti;Prajapati, Krunal;Darji, Nilesh;Soni, Palak;Shah, Parita. And the article was included in International Journal of Pharmaceutical Research and Bio-Science in 2012.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Name: 1-Ethyl-1H-pyrazol-5-amine<\/a> This article mentions the following:<\/p>\n<p>Amine and chloro derivatives of Et 4-substituted-6-phenyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate and carboxylic acid were synthesized using liquid ammonia and phosphorous oxychloride from 1-pentyl-5 amino pyrazole, resp. 3-Amino-2 substituted-4,7-dihydro-2H-Pyrazolo[4,3-c]pyridine-4,6-diol were synthesized from 3-cyanomethyl-4-cyano-5-amino-1-substituted pyrazole using active Me ene compound, Malononitrile and substituted hydrazine. Pyrazolo[3,4-b]pyridinone was synthesized from 3-amino-1-Ph pyrazolone and acetylacetone. Completion of reactions was checked by TLC using hexane:ethyl acetate as mobile phase. Reagents like Di-Et Benzoyl malonate &amp; \u03b2-Cyano Ethylhydrazine were also synthesized. All the synthesized compounds were characterized by IR, Mass and NMR anal. &amp; by m.p. &amp; TLC phys. The synthesized compounds were tested using Elevated Plus Maze model. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Name: 1-Ethyl-1H-pyrazol-5-amine<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Name: 1-Ethyl-1H-pyrazol-5-amine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Name: 1-Ethyl-1H-pyrazol-5-amine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11951","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kushwah, Shruti et al. published their research in International Journal of Pharmaceutical Research and Bio-Science in 2012 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis and pharmacological screening of pyrazolopyridine compounds as anxiolytics was written by Kushwah, Shruti;Prajapati, Krunal;Darji, Nilesh;Soni, Palak;Shah, Parita. 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