{"id":1195,"date":"2020-12-08T09:38:09","date_gmt":"2020-12-08T01:38:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1195"},"modified":"2020-12-08T09:38:09","modified_gmt":"2020-12-08T01:38:09","slug":"share-a-compound-1190380-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1195","title":{"rendered":"Share a compound : 1190380-49-4"},"content":{"rendered":"

Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1190380-49-4<\/a><\/p>\n

To a 20 mL vial containing 5-chloro-2-ethyl-N-[trans-4-(morpholin-4-yl)cyclohexyl]-[1,3]thiazolo[5,4-d]pyrimidin-7-amine (600 mg, 1.57 mmol, 1.00 equiv) and 1-(oxan-4-yl)-1H- pyrazol-4-amine (480 mg, 2.87 mmol, 1.83 equiv) in isopropanol (15 mL) was added 0.1 mL of HC1 (4m in dioxane) at room temperature. The final reaction mixture was irradiated in a microwave reactor for 3 h at 140C. After cooling, the solids were collected by filtration purified by flash column chromatography to yield 636.7 mg (79%) of 2-ethyl-5-N-[1-(oxan-4-yl)-1H- pyrazol-4-yl] -7-N-[trans-4-(morpholin-4-yl)cyclohexyl]- [1,3 ]thiazolo [5 ,4-d]pyrimidine-5 ,7-diamine as a light yellow solid. ?H-NMR (300 MHz, DMSO) 5 9.04 (s, 1H), 7.91 (s, 1H), 7.46 (s, 1H), 7.43 (br s, 1H), 4.42-4.25 (m, 1H), 4.12-3.85 (m, 3H), 3.57 (s, 4H), 3.43 (td, 2H), 2.97 (q, 2H), 2.49 (s, 4H), 2.30-2.15 (m, 1H), 2.08-1.82 (m, 8H), 1.58-1.40 (m, 2H), 1.39-1.22 (m, 5H). LCMS (ES, m\/z): 513 (M+Hj.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1190380-49-4, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1190380-49-4, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-1195","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 1190380-49-4<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1190380-49-4\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 1190380-49-4\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1190380-49-4\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-08T01:38:09+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195\",\"name\":\"Share a compound : 1190380-49-4\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-12-08T01:38:09+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1190380-49-4\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1195#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Share a compound : 1190380-49-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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