{"id":11945,"date":"2023-01-04T08:13:19","date_gmt":"2023-01-04T00:13:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11945"},"modified":"2023-01-04T08:13:19","modified_gmt":"2023-01-04T00:13:19","slug":"faure-robert-et-al-published-their-research-in-canadian-journal-of-chemistry-in-1988-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11945","title":{"rendered":"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4"},"content":{"rendered":"<p>High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles.  Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1988.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Quality Control of 3-Methyl-4-nitro-1H-pyrazole<\/a> This article mentions the following:<\/p>\n<p>Carbon-13 NMR spectroscopy in the solid state (cross polarization\/magic angle spinning technique) is a very suitable method for studying the annular tautomerism of pyrazoles. In all the compounds studied, the tautomerism is frozen and the signals are well resolved except for 3,5-dimethyl-4-nitropyrazole, which shows broad signals. In the case of 4-substituted derivatives of 3(5)-methylpyrazoles, the tautomer present in the solid state is a 4-X-5 methylpyrazole. 3-Phenyl-5-methylpyrazole (4<em>H<\/em> or 4-methyl) is favored over the 3-methyl-5-phenyl-tautomer. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Quality Control of 3-Methyl-4-nitro-1H-pyrazole<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Quality Control of 3-Methyl-4-nitro-1H-pyrazole<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Quality Control of 3-Methyl-4-nitro-1H-pyrazole<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11945","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles. Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1988.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles. Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1988.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-04T00:13:19+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945\",\"name\":\"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2023-01-04T00:13:19+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles. Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1988.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11945#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4 | pyrazoles-derivatives","description":"High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles. Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1988.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11945","og_locale":"en_US","og_type":"article","og_title":"Faure, Robert et al. published their research in Canadian Journal of Chemistry in 1988 | CAS: 5334-39-4 | pyrazoles-derivatives","og_description":"High resolution carbon-13 nuclear magnetic resonance spectra of solid pyrazoles. Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. 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Application to annular tautomerism was written by Faure, Robert;Vincent, Emile Jean;Rousseau, Andre;Claramunt, Rose Maria;Elguero, Jose. 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