{"id":11938,"date":"2023-01-04T08:11:31","date_gmt":"2023-01-04T00:11:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938"},"modified":"2023-01-04T08:11:31","modified_gmt":"2023-01-04T00:11:31","slug":"bauer-victor-j-et-al-published-their-research-in-journal-of-medicinal-chemistry-in-1968-cas-19959-77-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938","title":{"rendered":"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4"},"content":{"rendered":"<p>4-[3(5)-Pyrazolyl]pyridinium salts.  A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.<a href=\"https:\/\/www.ambeed.com\/products\/19959-77-4.html\">Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine<\/a> This article mentions the following:<\/p>\n<p>A series of 4-[3(5)-pyrazolyl]pyridinium salts (I) was synthesized. Many of these compounds display interesting hypoglycemic activity in alloxandiabetic mice; a structure-activity relationship is derived. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4<a href=\"https:\/\/www.ambeed.com\/products\/19959-77-4.html\">Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine<\/a>).<\/p>\n<p>2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/19959-77-4.html\">Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/19959-77-4.html\">Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11938","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-04T00:11:31+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938\",\"name\":\"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2023-01-04T00:11:31+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11938#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives","description":"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938","og_locale":"en_US","og_type":"article","og_title":"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives","og_description":"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-01-04T00:11:31+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938","name":"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2023-01-04T00:11:31+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11938"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11938#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Bauer, Victor J. et al. published their research in Journal of Medicinal Chemistry in 1968 | CAS: 19959-77-4"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11938"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11938\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}