{"id":11910,"date":"2023-01-04T04:59:16","date_gmt":"2023-01-03T20:59:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910"},"modified":"2023-01-04T04:59:16","modified_gmt":"2023-01-03T20:59:16","slug":"stypik-mariola-et-al-published-their-research-in-pharmaceuticals-in-2022-cas-141459-53-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910","title":{"rendered":"Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2"},"content":{"rendered":"<p>Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3K\u03b4 Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. And the article was included in Pharmaceuticals in 2022.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine<\/a> This article mentions the following:<\/p>\n<p>In this work, a new library of small-mol. inhibitors based on indol-4-yl-pyrazolo[1,5-a]pyrimidine with IC<sub>50<\/sub> values in the low nanomolar range and high selectivity against the PI3K\u03b4 isoform were designed and synthesized. CPL302253, the most potent compound of all the structures obtained, with IC<sub>50<\/sub> = 2.8 nM, is a potential future candidate for clin. development as an inhaled drug to prevent asthma. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine<\/a>).<\/p>\n<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11910","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3K\u03b4 Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. And the article was included in Pharmaceuticals in 2022.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11910\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3K\u03b4 Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. 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And the article was included in Pharmaceuticals in 2022.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910","og_locale":"en_US","og_type":"article","og_title":"Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2 | pyrazoles-derivatives","og_description":"Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3K\u03b4 Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. And the article was included in Pharmaceuticals in 2022.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-01-03T20:59:16+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910","name":"Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2023-01-03T20:59:16+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3K\u03b4 Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. And the article was included in Pharmaceuticals in 2022.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11910"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11910#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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