{"id":11899,"date":"2022-12-30T07:44:42","date_gmt":"2022-12-29T23:44:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899"},"modified":"2022-12-30T07:44:42","modified_gmt":"2022-12-29T23:44:42","slug":"hrelia-patrizia-et-al-published-their-research-in-mutation-research-fundamental-and-molecular-mechanisms-of-mutagenesis-in-1998-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899","title":{"rendered":"Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4"},"content":{"rendered":"<p>Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium was written by Hrelia, Patrizia;Fimognari, Carmela;Maffei, Francesca;Brighenti, Benedetta;Garuti, Laura;Burnelli, Silvia;Cantelli-Forti, Giorgio. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a> This article mentions the following:<\/p>\n<p>A new series of 4-nitro-(imidazoles and pyrazoles) were synthesized as novel antimycotics and tested for their activation to mutagenic forms using Salmonella typhimurium TA98 and TA100, in the presence and in the absence of metabolic activation. TA100NR, TA100\/1,8-DNP<sub>6<\/sub>, YG1026 and YG1029 strains were employed to identify a specific metabolic reaction which governs the mutagenic potency. Derivatives in the pyrazole group were generally found to be non mutagenic and active imidazoles were weak-direct-acting mutagens. For most of the compounds the mutagenic responses in TA98 were absent or 12- to 22-fold lower compared to TA100. The presence of a Me or a benzylic group on the imidazole ring and substituents on the N<sub>1<\/sub> and N<sub>3<\/sub> positions were determinant for mutagenicity. Metabolism by bacterial enzyme systems was important to the expression of genotoxicity. Active compounds showed no mutagenicity toward the strain defective in classical nitroreductase and increased mutagenicity, from 2- to 7-fold depending on the test compound, toward the corresponding overproducing bacteria. On the other hand, compounds displayed reduced mutagenicity to the O-acetyltransferase strain without having increased activity in the corresponding overproducing bacteria, YG1029. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11899","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium was written by Hrelia, Patrizia;Fimognari, Carmela;Maffei, Francesca;Brighenti, Benedetta;Garuti, Laura;Burnelli, Silvia;Cantelli-Forti, Giorgio. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998.Electric Literature of C4H5N3O2 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11899\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium was written by Hrelia, Patrizia;Fimognari, Carmela;Maffei, Francesca;Brighenti, Benedetta;Garuti, Laura;Burnelli, Silvia;Cantelli-Forti, Giorgio. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998.Electric Literature of C4H5N3O2 This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11899\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-29T23:44:42+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11899\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11899\",\"name\":\"Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-12-29T23:44:42+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium was written by Hrelia, Patrizia;Fimognari, Carmela;Maffei, Francesca;Brighenti, Benedetta;Garuti, Laura;Burnelli, Silvia;Cantelli-Forti, Giorgio. 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And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998.Electric Literature of C4H5N3O2 This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-12-29T23:44:42+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899","name":"Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-12-29T23:44:42+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium was written by Hrelia, Patrizia;Fimognari, Carmela;Maffei, Francesca;Brighenti, Benedetta;Garuti, Laura;Burnelli, Silvia;Cantelli-Forti, Giorgio. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998.Electric Literature of C4H5N3O2 This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11899"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11899#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Hrelia, Patrizia et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1998 | CAS: 5334-39-4"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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