{"id":11897,"date":"2022-12-30T07:43:12","date_gmt":"2022-12-29T23:43:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11897"},"modified":"2022-12-30T07:43:12","modified_gmt":"2022-12-29T23:43:12","slug":"ple-patrick-a-et-al-published-their-research-in-bioorganic-medicinal-chemistry-letters-in-2012-cas-55361-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11897","title":{"rendered":"Ple, Patrick A. et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2012 | CAS: 55361-49-4"},"content":{"rendered":"<p>Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2012.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Quality Control of 1-Ethyl-1H-pyrazol-3-amine<\/a> This article mentions the following:<\/p>\n<p>A new series of quinazolinyloxy- and quinazolinylamonopyrazoleacetamides which inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932 (<strong>I<\/strong>). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Quality Control of 1-Ethyl-1H-pyrazol-3-amine<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Quality Control of 1-Ethyl-1H-pyrazol-3-amine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Quality Control of 1-Ethyl-1H-pyrazol-3-amine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11897","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ple, Patrick A. et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2012 | CAS: 55361-49-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2012.Quality Control of 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11897\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ple, Patrick A. et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2012 | CAS: 55361-49-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ple, Patrick A. et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2012 | CAS: 55361-49-4 | pyrazoles-derivatives","description":"Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. 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