{"id":11863,"date":"2022-12-30T07:41:31","date_gmt":"2022-12-29T23:41:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11863"},"modified":"2022-12-30T07:41:31","modified_gmt":"2022-12-29T23:41:31","slug":"dorn-helmut-et-al-published-their-research-in-journal-fuer-praktische-chemie-leipzig-in-1982-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11863","title":{"rendered":"Dorn, Helmut et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1982 | CAS: 3528-58-3"},"content":{"rendered":"<p>Unambiguous synthesis of 4,7-dihydro-4-oxo-1H-pyrazolo[3,4-b]pyridine &#8211; further comments on the &#8220;(N-C) rearrangement&#8221; of [2-(alkoxycarbonyl)vinylamino]pyrazoles was written by Dorn, Helmut;Ozegowski, Ruediger. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1982.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a> This article mentions the following:<\/p>\n<p>Successive decarboxylation of pyrazolopyridine <strong>I<\/strong> and debenzylation of <strong>II<\/strong> (R<sup>1<\/sup> = CH<sub>2<\/sub>Ph, R<sup>2<\/sup> = H) with Na in NH<sub>3<\/sub>(l) gave the title compound <strong>II<\/strong> (R<sup>1<\/sup> = R<sup>2<\/sup> = H). The product from 3-aminopyrazole and HC\ue306CCO<sub>2<\/sub>Me, formerly described as <strong>II<\/strong> (R<sup>1<\/sup> = R<sup>2<\/sup> = H), is the 6-oxo isomer <strong>III<\/strong> (R<sup>1<\/sup> = R<sup>2<\/sup> = H). Debenzylation of <strong>II<\/strong> (R<sup>1<\/sup> = CH<sub>2<\/sub>Ph, R<sup>2<\/sup> = H) and analogs with SeO<sub>2<\/sub> is only possible if the position \u03b1 to the C:O is blocked; otherwise, selenides of type <strong>IV<\/strong> are formed. Cyclizing pyrazoles <strong>V<\/strong> (R<sup>1<\/sup> = R<sup>2<\/sup> = H, R<sup>1<\/sup> = CH<sub>2<\/sub>Ph, R<sup>2<\/sup> = H, Me; R<sup>3<\/sup> = Me, Et) in acidic media with catalytic amounts the corresponding aminopyrazoles gave pyrazolopyridines <strong>III<\/strong> via pyrazoles <strong>VI<\/strong>, i.e., via products of a N-C rearrangement, whereas thermal cyclization of <strong>V<\/strong> gave <strong>II<\/strong> (R<sup>1<\/sup>,R<sup>2<\/sup> as above and also R<sup>1<\/sup> = CH<sub>2<\/sub>Ph, R<sup>2<\/sup> = Me). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11863","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dorn, Helmut et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1982 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Unambiguous synthesis of 4,7-dihydro-4-oxo-1H-pyrazolo[3,4-b]pyridine - further comments on the &quot;(N-C) rearrangement&quot; of [2-(alkoxycarbonyl)vinylamino]pyrazoles was written by Dorn, Helmut;Ozegowski, Ruediger. 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And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1982.Recommanded Product: 3528-58-3 This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11863","og_locale":"en_US","og_type":"article","og_title":"Dorn, Helmut et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1982 | CAS: 3528-58-3 | pyrazoles-derivatives","og_description":"Unambiguous synthesis of 4,7-dihydro-4-oxo-1H-pyrazolo[3,4-b]pyridine - further comments on the \"(N-C) rearrangement\" of [2-(alkoxycarbonyl)vinylamino]pyrazoles was written by Dorn, Helmut;Ozegowski, Ruediger. 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And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1982.Recommanded Product: 3528-58-3 This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11863#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11863"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11863#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Dorn, Helmut et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1982 | CAS: 3528-58-3"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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