{"id":1181,"date":"2020-12-04T10:13:01","date_gmt":"2020-12-04T02:13:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1181"},"modified":"2020-12-04T10:13:01","modified_gmt":"2020-12-04T02:13:01","slug":"analyzing-the-synthesis-route-of-4-amino-1-methyl-3-n-propyl-1h-pyrazole-5-carboxamide","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1181","title":{"rendered":"Analyzing the synthesis route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., 139756-02-8<\/a><\/p>\n

General procedure: A 12mL vial was charged with MCM-41-2P-Pd(OAc)2 (2mol%), 2-aminobenzamide (1mmol), aryl iodide (1mmol) (if solid) and a stirring bar. Then, DMF (2mL), aryl iodide (1mmol) (if liquid) and DBU (2mmol) were injected by syringe under an argon atmosphere. The vial was placed in an alloy plate, which was transferred into a 300mL Parr Instruments 4560 series autoclave under an argon atmosphere. After flushing the autoclave three times with CO, a pressure of 10bar CO was fixed at ambient temperature. The autoclave was heated for 20hat 120C. After completion of the reaction, the autoclave was cooled to room temperature and the pressure was released carefully. The reaction mixture was diluted with ethyl acetate (10mL) and filtered. The palladium catalyst was washed with distilled water (2\u00a1\u00c15mL) and acetone (2\u00a1\u00c15mL), and reused in the next run. The filtrate was concentrated in vacuo and the pure product was isolated by either washed with water, ethyl acetate and finally hexane or recrystallization from MeOH.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[157,131],"tags":[126],"class_list":["post-1181","post","type-post","status-publish","format-standard","hentry","category-139756-02-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, This compound has unique chemical properties. 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