{"id":11807,"date":"2022-12-05T06:01:02","date_gmt":"2022-12-04T22:01:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11807"},"modified":"2022-12-05T06:01:02","modified_gmt":"2022-12-04T22:01:02","slug":"parmar-deepa-r-s-team-published-research-in-chemistryselect-in-5-cas-763120-58-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11807","title":{"rendered":"Parmar, Deepa R.&#8217;s team published research in ChemistrySelect  in 5 | CAS: 763120-58-7"},"content":{"rendered":"<p>Parmar, Deepa R. published the artcile<b><i>Design, Synthesis, In Silico Studies and In Vitro Anticancer Activity of 3-(4-Methoxyphenyl)azetidine Derivatives<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/763120-58-7.html\">Recommanded Product: 1H-Pyrazole-4-boronic acid<\/a>,  the publication is  ChemistrySelect (2020), 5(45), 14296-14302, database is CAplus.<\/p>\n<p>A series of 3-(4-methoxyphenyl)azetidine analogs <strong>I<\/strong> [Ar = Ph, 4-MeC<sub>6<\/sub>H<sub>4<\/sub>, 4-FC<sub>6<\/sub>H<sub>4<\/sub>, etc.] were synthesized and screened for their in vitro anticancer activity against nine different human cancer cell lines using the cell counting kit-8 (CCK-8) assay. The toxicity, bioavailability and lipophilicity of all the synthesized compounds <strong>I<\/strong> were predicted by using osiris and molinspiration model. Mol. docking study revealed that, compound <strong>I<\/strong> [Ar = 2-aminopyridin-4-yl, 2-methoxypyridin-4-yl] were found to be potential inhibitor of human topoisomerase II\u03b1. The cell viability studies exhibited promising antiproliferative activities of the compound <strong>I<\/strong> [Ar = 2-aminopyridin-4-yl] (EC<sub>50<\/sub> 0.03\u03bcM) was found to be more potent than standard Doxorubicin (EC<sub>50<\/sub> 0.07\u03bcM) in U251 cancer cell lines. Similarly, compound <strong>I<\/strong> [Ar = 2-methoxypyridin-4-yl] showed considerable potency against four different cancer cell lines (HepG2, U251, A431, 786-O) with EC<sub>50<\/sub> values ranging from 0.46 to 2.13\u03bcM.<\/p>\n<p>ChemistrySelect published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, <a href=\"https:\/\/www.ambeed.com\/products\/763120-58-7.html\">Recommanded Product: 1H-Pyrazole-4-boronic acid<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ChemistrySelect published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, <a href=\"https:\/\/www.ambeed.com\/products\/763120-58-7.html\">Recommanded Product: 1H-Pyrazole-4-boronic acid<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[802,131],"tags":[732],"class_list":["post-11807","post","type-post","status-publish","format-standard","hentry","category-763120-58-7","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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