{"id":11798,"date":"2022-12-05T02:37:14","date_gmt":"2022-12-04T18:37:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11798"},"modified":"2022-12-05T02:37:14","modified_gmt":"2022-12-04T18:37:14","slug":"gummadi-venkateshwar-raos-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-23-cas-1415825-05-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11798","title":{"rendered":"Gummadi, Venkateshwar Rao’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 1415825-05-6"},"content":{"rendered":"

Gummadi, Venkateshwar Rao published the artcileDiscovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode<\/i><\/b>, Related Products of pyrazoles-derivatives<\/a>, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(17), 4911-4918, database is CAplus and MEDLINE.<\/p>\n

We have identified a novel 7-azaindole series of anaplastic lymphoma kinase (ALK) inhibitors. Compounds 7b, 7m and 7n demonstrate excellent potencies in biochem. and cellular assays. X-ray crystal structure of one of the compounds (7k) revealed a unique binding mode with the benzyl group occupying the back pocket, explaining its potency towards ALK and selectivity over tested kinases particularly Aurora-A. This binding mode is in contrast to that of known ALK inhibitors such as Crizotinib and NVP-TAE684 which occupy the ribose binding pocket, close to DFG motif.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about 1415825-05-6. 1415825-05-6 belongs to pyrazoles-derivatives, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 1-(2-Fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, and the molecular formula is C16H20BFN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about 1415825-05-6. 1415825-05-6 belongs to pyrazoles-derivatives, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 1-(2-Fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, and the molecular formula is C16H20BFN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[782,131],"tags":[811],"class_list":["post-11798","post","type-post","status-publish","format-standard","hentry","category-1415825-05-6","category-pyrazoles-derivatives","tag-m-w300-350"],"yoast_head":"\nGummadi, Venkateshwar Rao's team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 1415825-05-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Gummadi, Venkateshwar Rao published the artcileDiscovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode, Related Products of pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(17), 4911-4918, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gummadi, Venkateshwar Rao's team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 1415825-05-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Gummadi, Venkateshwar Rao published the artcileDiscovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode, Related Products of pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(17), 4911-4918, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-04T18:37:14+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798\",\"name\":\"Gummadi, Venkateshwar Rao's team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 1415825-05-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-12-04T18:37:14+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Gummadi, Venkateshwar Rao published the artcileDiscovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode, Related Products of pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(17), 4911-4918, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11798#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gummadi, Venkateshwar Rao’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 1415825-05-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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