{"id":11770,"date":"2022-12-02T03:56:09","date_gmt":"2022-12-01T19:56:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770"},"modified":"2022-12-02T03:56:09","modified_gmt":"2022-12-01T19:56:09","slug":"cusmano-sigismondos-team-published-research-in-gazzetta-chimica-italiana-in-70-cas-13599-22-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770","title":{"rendered":"Cusmano, Sigismondo&#8217;s team published research in Gazzetta Chimica Italiana  in 70 | CAS: 13599-22-9"},"content":{"rendered":"<p>Cusmano, Sigismondo published the artcile<b><i>Transformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/13599-22-9.html\">HPLC of Formula: 13599-22-9<\/a>,  the publication is  Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.<\/p>\n<p>cf. C. A. 34, 7903.8. The transformation of 3-isoxazolecarboxylic acids into pyrazolonimines by fusion with PhNHNH<sub>2<\/sub> may proceed by decarboxylation followed by ring closure of the resulting cyano ketone phenylhydrazone. To test this hypothesis the fusion was repeated in the presence of Natur Kupfer C (I) (or ordinary reduced Cu) so that, at the lower decarboxylation temperatures it might be possible to isolate the phenylhydrazone prior to ring closure and so shed some light on the mechanism of the reaction. A mixture of 1 g. of 5-phenyl-3-isoxazolecarboxylic acid (II), 1 g. I and 1 g. PhNHNH<sub>2<\/sub> in 20 cc. alc. was boiled for a few min. over a free flame, filtered, alkalinized with Na<sub>2<\/sub>CO<sub>3<\/sub>, extracted free from PhNHNH<sub>2<\/sub> with ether, acidified with dilute H<sub>2<\/sub>SO<sub>4<\/sub>, and extracted with ether. The residue from the evaporated extract gave 1,5-diphenyl-3-pyrazolecarboxylic acid (III), m. 185\u00b0 (Et ester, m. 98\u00b0), decarboxylated by fusion to give 1,5-diphenylpyrazole, m. 55\u00b0, and identical with the known acid prepared by the action of PhNHNH<sub>2<\/sub> on BzCH<sub>2<\/sub>COCO<sub>2<\/sub>H. A similar transformation of 5-methyl-3-isoxazolecarboxylic acid (IV) gave 1-phenyl-5-methyl-3-pyrazolecarboxylic acid, m. 136\u00b0 (Me ester, m. 55\u00b0), decarboxylated to 1-phenyl-5-methylpyrazole, transformed into the known picrate, m. 98\u00b0. In these transformations alc. can be replaced by other solvents. In the absence of I or in the presence of PhNH<sub>2<\/sub> instead of PhNHNH<sub>2<\/sub> the isoxazolecarboxylic acid is recovered unchanged.<\/p>\n<p>Gazzetta Chimica Italiana published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, <a href=\"https:\/\/www.ambeed.com\/products\/13599-22-9.html\">HPLC of Formula: 13599-22-9<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gazzetta Chimica Italiana published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, <a href=\"https:\/\/www.ambeed.com\/products\/13599-22-9.html\">HPLC of Formula: 13599-22-9<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[819,131],"tags":[740],"class_list":["post-11770","post","type-post","status-publish","format-standard","hentry","category-13599-22-9","category-pyrazoles-derivatives","tag-m-w250-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cusmano, Sigismondo&#039;s team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cusmano, Sigismondo&#039;s team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-01T19:56:09+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770\",\"name\":\"Cusmano, Sigismondo's team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-12-01T19:56:09+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11770#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cusmano, Sigismondo&#8217;s team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cusmano, Sigismondo's team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives","description":"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770","og_locale":"en_US","og_type":"article","og_title":"Cusmano, Sigismondo's team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives","og_description":"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-12-01T19:56:09+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770","name":"Cusmano, Sigismondo's team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-12-01T19:56:09+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Cusmano, Sigismondo published the artcileTransformation of 3-isoxazolecarboxylic acids into pyrazole derivatives. IV, HPLC of Formula: 13599-22-9, the publication is Gazzetta Chimica Italiana (1940), 227-35, database is CAplus.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11770"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11770#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Cusmano, Sigismondo&#8217;s team published research in Gazzetta Chimica Italiana in 70 | CAS: 13599-22-9"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11770"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11770\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}