{"id":11740,"date":"2022-12-02T03:52:42","date_gmt":"2022-12-01T19:52:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11740"},"modified":"2022-12-02T03:52:42","modified_gmt":"2022-12-01T19:52:42","slug":"wang-zhens-team-published-research-in-journal-of-medicinal-chemistry-in-64-cas-763120-58-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11740","title":{"rendered":"Wang, Zhen’s team published research in Journal of Medicinal Chemistry in 64 | CAS: 763120-58-7"},"content":{"rendered":"

Wang, Zhen published the artcileDiscovery of an Orally Bioavailable Small-Molecule Inhibitor for the \u03b2-Catenin\/B-Cell Lymphoma 9 Protein-Protein Interaction<\/i><\/b>, Product Details of C3H5BN2O2<\/a>, the publication is Journal of Medicinal Chemistry (2021), 64(16), 12109-12131, database is CAplus and MEDLINE.<\/p>\n

Aberrant activation of Wnt\/\u03b2-catenin signaling is strongly associated with many diseases including cancer invasion and metastasis. Small-mol. targeting of the central signaling node of this pathway, \u03b2-catenin, is a biol. rational approach to abolish hyperactivation of \u03b2-catenin signaling but has been demonstrated to be a difficult task. Herein, we report a drug-like small mol., ZW4864, that binds with \u03b2-catenin and selectively disrupts the protein-protein interaction (PPI) between B-cell lymphoma 9 (BCL9) and \u03b2-catenin while sparing the \u03b2-catenin\/E-cadherin PPI. ZW4864 dose-dependently suppresses \u03b2-catenin signaling activation, downregulates oncogenic \u03b2-catenin target genes, and abrogates invasiveness of \u03b2-catenin-dependent cancer cells. More importantly, ZW4864 shows good pharmacokinetic properties and effectively suppresses \u03b2-catenin target gene expression in the patient-derived xenograft mouse model. This study offers a selective chem. probe to explore \u03b2-catenin-related biol. and a drug-like small-mol. \u03b2-catenin\/BCL9 disruptor for future drug development.<\/p>\n

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C22H12F6O6S2, Product Details of C3H5BN2O2<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C22H12F6O6S2, Product Details of C3H5BN2O2<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[802,131],"tags":[732],"class_list":["post-11740","post","type-post","status-publish","format-standard","hentry","category-763120-58-7","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nWang, Zhen's team published research in Journal of Medicinal Chemistry in 64 | CAS: 763120-58-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Wang, Zhen published the artcileDiscovery of an Orally Bioavailable Small-Molecule Inhibitor for the \u03b2-Catenin\/B-Cell Lymphoma 9 Protein-Protein Interaction, Product Details of C3H5BN2O2, the publication is Journal of Medicinal Chemistry (2021), 64(16), 12109-12131, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wang, Zhen's team published research in Journal of Medicinal Chemistry in 64 | CAS: 763120-58-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Wang, Zhen published the artcileDiscovery of an Orally Bioavailable Small-Molecule Inhibitor for the \u03b2-Catenin\/B-Cell Lymphoma 9 Protein-Protein Interaction, Product Details of C3H5BN2O2, the publication is Journal of Medicinal Chemistry (2021), 64(16), 12109-12131, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-01T19:52:42+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740\",\"name\":\"Wang, Zhen's team published research in Journal of Medicinal Chemistry in 64 | CAS: 763120-58-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-12-01T19:52:42+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Wang, Zhen published the artcileDiscovery of an Orally Bioavailable Small-Molecule Inhibitor for the \u03b2-Catenin\/B-Cell Lymphoma 9 Protein-Protein Interaction, Product Details of C3H5BN2O2, the publication is Journal of Medicinal Chemistry (2021), 64(16), 12109-12131, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11740#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Wang, Zhen’s team published research in Journal of Medicinal Chemistry in 64 | CAS: 763120-58-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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