{"id":1173,"date":"2020-12-03T15:30:35","date_gmt":"2020-12-03T07:30:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1173"},"modified":"2020-12-03T15:30:35","modified_gmt":"2020-12-03T07:30:35","slug":"new-downstream-synthetic-route-of-4-iodopyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1173","title":{"rendered":"New downstream synthetic route of 4-Iodopyrazole"},"content":{"rendered":"

3469-69-0<\/a>, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3469-69-0, name is 4-Iodopyrazole, A new synthetic method of this compound is introduced below.<\/p>\n

ieri-Butyl 4-iodo-1 H-pyrazole-1 -carboxylate (2); [00189] 4-lodopyrazole (1) (7.85g 40.4mmole) was dissolved in THF (120ml_) and triethylamine (8.5ml_, 6.12g 60.5mmole) and di-terf-butyl dicarbonate (9.7g, 44.5mmole) were added. The reaction was stirred at r.t. for 3 hours. The THF was evaporated and ethyl acetate (100ml_) was added. The solution was washed with water (2x50ml_) and with brine, then dried and evaporated to leave an oil (14.2g). The crude product was purified by chromatography on a pad of silica in a sinter (10cm diam, 6cm thick) eluted with 10% ethyl acetate in cyclohexane (1 1 x90ml_), then 20% ethyl acetate in cyclohexane (3x90ml_) to give the protected pyrazole 2 (1 1 .66g 98%). 1H-NMR (CDCI3, 500MHz): delta 1 .68 (s, 9H), 7.73 (s, 1 H), 8.17 (s, 1 H).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[134,131],"tags":[126],"class_list":["post-1173","post","type-post","status-publish","format-standard","hentry","category-3469-69-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 4-Iodopyrazole<\/title>\n<meta name=\"description\" content=\"3469-69-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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