{"id":11707,"date":"2022-12-02T03:51:02","date_gmt":"2022-12-01T19:51:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11707"},"modified":"2022-12-02T03:51:02","modified_gmt":"2022-12-01T19:51:02","slug":"wu-gengxins-team-published-research-in-organic-letters-in-21-cas-14580-22-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11707","title":{"rendered":"Wu, Gengxin’s team published research in Organic Letters in 21 | CAS: 14580-22-4"},"content":{"rendered":"

Wu, Gengxin published the artcileAsymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich\/\u03b1-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters<\/i><\/b>, Product Details of C10H9ClN2O<\/a>, the publication is Organic Letters (2019), 21(19), 7708-7712, database is CAplus and MEDLINE.<\/p>\n

In this letter, an efficient one-pot asym. sequential reaction is achieved by organo\/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines and a subsequent palladium catalyzed diastereoselective allylic alkylation of pyrazolones with allylic acetates. An array of novel pyrazolone-aminooxindole-propylene structural motifs are obtained in a high level of yield and with excellent enantio- and diastereoselectivity (up to 95% yield, >20:1 dr, >99% ee). This methodol. features the formation of vicinal quaternary carbon-stereocenters, and the second all-carbon tetrasubstituted stereogenic center is induced by joint action of the achiral palladium catalysis and the chiral environment generated from the Mannich step. Moreover, the usefulness of this methodol. is highlighted by converting the allylic product into the carbonyl compound<\/p>\n

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C15H14Cl2S2, Product Details of C10H9ClN2O<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C15H14Cl2S2, Product Details of C10H9ClN2O<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[799,131],"tags":[716],"class_list":["post-11707","post","type-post","status-publish","format-standard","hentry","category-14580-22-4","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nWu, Gengxin's team published research in Organic Letters in 21 | CAS: 14580-22-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Wu, Gengxin published the artcileAsymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich\/\u03b1-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters, Product Details of C10H9ClN2O, the publication is Organic Letters (2019), 21(19), 7708-7712, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wu, Gengxin's team published research in Organic Letters in 21 | CAS: 14580-22-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Wu, Gengxin published the artcileAsymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich\/\u03b1-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters, Product Details of C10H9ClN2O, the publication is Organic Letters (2019), 21(19), 7708-7712, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-01T19:51:02+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707\",\"name\":\"Wu, Gengxin's team published research in Organic Letters in 21 | CAS: 14580-22-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-12-01T19:51:02+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Wu, Gengxin published the artcileAsymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich\/\u03b1-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters, Product Details of C10H9ClN2O, the publication is Organic Letters (2019), 21(19), 7708-7712, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11707#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Wu, Gengxin’s team published research in Organic Letters in 21 | CAS: 14580-22-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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