{"id":11606,"date":"2022-12-01T03:29:33","date_gmt":"2022-11-30T19:29:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11606"},"modified":"2022-12-01T03:29:33","modified_gmt":"2022-11-30T19:29:33","slug":"chattaway-f-d-s-team-published-research-in-journal-of-the-chemical-society-transactions-in-125-cas-14580-22-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11606","title":{"rendered":"Chattaway, F. D.&#8217;s team published research in Journal of the Chemical Society, Transactions  in 125 | CAS: 14580-22-4"},"content":{"rendered":"<p>Chattaway, F. D. published the artcile<b><i>Halogen-substituted 1-arylpyrazolones<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/14580-22-4.html\">Related Products of pyrazoles-derivatives<\/a>,  the publication is  Journal of the Chemical Society, Transactions (1924), 2423-7, database is CAplus.<\/p>\n<p>The 1-chlorophenyl-3-methyl-5-pyrazolones are very similar in properties to the unsubstituted base, neither the position of the substituted halogen nor its accumulation in the Ph residue appearing greatly to affect the reactivity of the CH<sub>2<\/sub> group. 1-o-Chlorophenyl-3-methyl-5-pyrazoline (I), m. 199\u00b0, results by heating MeC(:NNHC<sub>6<\/sub>H<sub>4<\/sub>Cl)CH<sub>2<\/sub>CO<sub>2<\/sub>Et at 150-70\u00b0 for about 90 mins.; HCl salt, m. 154\u00b0, decomposes 172\u00b0; 4-oximino derivative, golden brown, m. 174\u00b0; 4-benzylidene derivative, orange, m. 159\u00b0; 4-azo-o-chlorobenzene derivative, golden yellow, m. 212\u00b0. I, heated with MeI in MeOH in a sealed tube at 100-20\u00b0 for 10 hrs., gives the 2,3-di-Me derivative (o-chloroantipyrine), m. 113\u00b0, whose aqueous solution has a strong bitter taste. 1-m-Chloro derivative (II), m. 131\u00b0; HCl salt, m. 184\u00b0 (decomposition); 4-oximino derivative, orange, m. 173\u00b0 (decomposition); 4-benzylidene derivative, red, m. 128\u00b0; 4-azo-2&#8242;,4&#8242;-dichlorobenzene, golden brown, m. 190\u00b0; II, heated with Me<sub>2<\/sub>CO 4 hrs., gives the 4-isopropylidene derivative, S-yellow, m. 110\u00b0; 2,3-di-Me derivative (m-chloroantipyrine), m. 89-90\u00b0; its aqueous solution has an extremely bitter taste. II, heated with PhNHNH<sub>2<\/sub> until NH<sub>3<\/sub> is no longer liberated, and NaNO<sub>2<\/sub> in NaOH, added to an excess of dilute H<sub>2<\/sub>SO<sub>4<\/sub>, give m-chloropyrazole-blue, C<sub>20<\/sub>H<sub>14<\/sub>O<sub>2<\/sub>N<sub>4<\/sub>Cl<sub>2<\/sub>, dark blue, m. 209\u00b0 (decomposition); this also results by boiling II with FeCl<sub>3<\/sub>; the other Cl derivatives do not show this reaction. It is easily reduced to the bispyrazolone. 1-p-Chloro HCl salt, m. 194-5\u00b0 (decomposition); 4-oximino derivative, orange needles, m. 180\u00b0 (decomposition); it also exists as the unstable form, brick-red, compact triclinic prisms; 4-benzylidene derivative, scarlet, m. 156\u00b0; 4-azo-p-chlorobenzene, orange-red, m. 232\u00b0; 2, 3-di-Me derivative (p-chloroantipyrine), m. 126\u00b0; this also has a very bitter taste. Bis-1-chlorophenyl-3-methyl-5-pyrazolone, decomposes without melting; p-chloropyrazole-blue, blue, decomposed at about 300\u00b0. 1,2,4-Dichlorophenyl-3-methyl-5-pyrazolone, m. 178\u00b0; HCl salt, m. 153\u00b0, decomposes 170\u00b0; 4-oximino derivative, canary-yellow, m. 166-8\u00b0 (decomposition); 4-benzylidene derivative, orange, m. 131\u00b0; 4-azobenzene derivative, orange, m. 137-8\u00b0; 2, 3-di-Me derivative, m. 143\u00b0; the aqueous solution has a bitter taste.<\/p>\n<p>Journal of the Chemical Society, Transactions published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, <a href=\"https:\/\/www.ambeed.com\/products\/14580-22-4.html\">Related Products of pyrazoles-derivatives<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal of the Chemical Society, Transactions published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, <a href=\"https:\/\/www.ambeed.com\/products\/14580-22-4.html\">Related Products of pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[799,131],"tags":[716],"class_list":["post-11606","post","type-post","status-publish","format-standard","hentry","category-14580-22-4","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chattaway, F. 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