{"id":11603,"date":"2022-12-01T03:29:33","date_gmt":"2022-11-30T19:29:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11603"},"modified":"2022-12-01T03:29:33","modified_gmt":"2022-11-30T19:29:33","slug":"di-fabio-romanos-team-published-research-in-journal-of-medicinal-chemistry-in-51-cas-3553-12-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11603","title":{"rendered":"Di Fabio, Romano’s team published research in Journal of Medicinal Chemistry in 51 | CAS: 3553-12-6"},"content":{"rendered":"

Di Fabio, Romano published the artcileSynthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists<\/i><\/b>, Quality Control of 3553-12-6<\/a>, the publication is Journal of Medicinal Chemistry (2008), 51(23), 7370-7379, database is CAplus and MEDLINE.<\/p>\n

To identify new CRF1<\/sub> receptor antagonists, an attempt to modify the bis-heterocycle moiety present in the top region of the dihydropyrrole[2,3]pyridine template was made following new pharmacophoric hypothesis on the CRF1<\/sub> receptor antagonists binding pocket. In particular, the 2-thiazole ring, present in the previous series of compounds, was replaced by more hydrophilic non aromatic heterocycles able to make appropriate H-bond interactions with amino acid residues Thr192 and Tyr195. This exploration, followed by an accurate anal. of the substitution of the pendant aryl ring, enabled identification of in vitro potent compounds, e.g., I<\/strong>, showing excellent pharmacokinetics and outstanding in vivo activity in animal models of anxiety, both in rodents and primates.<\/p>\n

Journal of Medicinal Chemistry published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, Quality Control of 3553-12-6<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal of Medicinal Chemistry published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, Quality Control of 3553-12-6<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[814,131],"tags":[732],"class_list":["post-11603","post","type-post","status-publish","format-standard","hentry","category-3553-12-6","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nDi Fabio, Romano's team published research in Journal of Medicinal Chemistry in 51 | CAS: 3553-12-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Di Fabio, Romano published the artcileSynthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists, Quality Control of 3553-12-6, the publication is Journal of Medicinal Chemistry (2008), 51(23), 7370-7379, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Di Fabio, Romano's team published research in Journal of Medicinal Chemistry in 51 | CAS: 3553-12-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Di Fabio, Romano published the artcileSynthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists, Quality Control of 3553-12-6, the publication is Journal of Medicinal Chemistry (2008), 51(23), 7370-7379, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-30T19:29:33+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603\",\"name\":\"Di Fabio, Romano's team published research in Journal of Medicinal Chemistry in 51 | CAS: 3553-12-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-30T19:29:33+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Di Fabio, Romano published the artcileSynthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists, Quality Control of 3553-12-6, the publication is Journal of Medicinal Chemistry (2008), 51(23), 7370-7379, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11603#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Di Fabio, Romano’s team published research in Journal of Medicinal Chemistry in 51 | CAS: 3553-12-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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