{"id":11589,"date":"2022-11-30T04:44:34","date_gmt":"2022-11-29T20:44:34","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11589"},"modified":"2022-11-30T04:44:34","modified_gmt":"2022-11-29T20:44:34","slug":"pettinari-riccardos-team-published-research-in-organometallics-in-32-cas-4551-69-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11589","title":{"rendered":"Pettinari, Riccardo&#8217;s team published research in Organometallics  in 32 | CAS: 4551-69-3"},"content":{"rendered":"<p>Pettinari, Riccardo published the artcile<b><i>Cytotoxicity of Ruthenium-Arene Complexes Containing \u03b2-Ketoamine Ligands<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/4551-69-3.html\">Product Details of C17H14N2O2<\/a>,  the publication is  Organometallics (2013), 32(1), 309-316, database is CAplus.<\/p>\n<p>New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing \u03b2-ketoamine ligands L&#8217; (HL&#8217; in general; in detail, HL<sup>ph,ph<\/sup> = (4Z)-3-methyl-4-((phenylamino)(phenyl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HL<sup>naph,ph<\/sup> = (4Z)-3-methyl-4-((phenyamino)(naphthalen-2-yl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HL<sup>et,ph<\/sup> = (4Z)-3-methyl-4-(1-(phenylamino)propylidene)-1-phenyl-1H-pyrazol-5(4H)-one) have been synthesized and characterized by spectroscopy (IR, ESI-MS, <sup>1<\/sup>H and <sup>13<\/sup>C NMR) and elemental anal. The ligands in the anionic form coordinate ruthenium in a chelating \u03ba<sup>2<\/sup>N,O-bidentate fashion, affording 1:1 derivatives of the formula [Ru(arene)(L&#8217;)Cl]. Further reaction of [Ru(p-cymene)(L&#8217;)Cl] with AgPF<sub>6<\/sub> or PTA (PTA = 1,3,5-triaza-7-phosphaadamantane) in methanol affords [Ru(p-cymene)(L&#8217;)(CH<sub>3<\/sub>OH)][PF<sub>6<\/sub>] and [Ru(p-cymene)(L&#8217;)(PTA)]Cl, resp. The solid-state structures of the ligand HL<sup>et,ph<\/sup> and complexes [Ru(p-cymene)(L<sup>ph,ph<\/sup>)Cl], [Ru(p-cymene)(L<sup>naph,ph<\/sup>)Cl], and [Ru(p-cymene)(L<sup>et,ph<\/sup>)Cl] have been determined by single-crystal x-ray diffraction. The antitumor activity of both the ligands and complexes has been evaluated against the human ovarian carcinoma cell line A2780 and its cisplatin-resistant equivalent A2780R, some of the complexes showing significant cytotoxicity toward the cisplatin-resistant cell line.<\/p>\n<p>Organometallics published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, <a href=\"https:\/\/www.ambeed.com\/products\/4551-69-3.html\">Product Details of C17H14N2O2<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Organometallics published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, <a href=\"https:\/\/www.ambeed.com\/products\/4551-69-3.html\">Product Details of C17H14N2O2<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[808,131],"tags":[740],"class_list":["post-11589","post","type-post","status-publish","format-standard","hentry","category-4551-69-3","category-pyrazoles-derivatives","tag-m-w250-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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