{"id":11565,"date":"2022-11-30T04:43:00","date_gmt":"2022-11-29T20:43:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565"},"modified":"2022-11-30T04:43:00","modified_gmt":"2022-11-29T20:43:00","slug":"davoren-jennifer-e-s-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-26-cas-19959-71-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565","title":{"rendered":"Davoren, Jennifer E.&#8217;s team published research in Bioorganic &amp; Medicinal Chemistry Letters  in 26 | CAS: 19959-71-8"},"content":{"rendered":"<p>Davoren, Jennifer E. published the artcile<b><i>Design and optimization of selective azaindole amide M<sub>1<\/sub> positive allosteric modulators<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/19959-71-8.html\">Application In Synthesis of  19959-71-8<\/a>,  the publication is  Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.<\/p>\n<p>Selective activation of the M<sub>1<\/sub> receptor via a pos. allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer&#8217;s disease. A novel series of azaindole amides and their key pharmacophore elements are described. The nitrogen of the azaindole core is a key design element as it forms an intramol. hydrogen bond with the amide N-H thus reinforcing the bioactive conformation predicted by published SAR and the authors&#8217; homol. model. Representative compound 25 is a potent and selective M<sub>1<\/sub> PAM that has well aligned physicochem. properties, adequate brain penetration and pharmacokinetic (PK) properties, and is active in vivo. These favorable properties indicate that this series possesses suitable qualities for further development and studies.<\/p>\n<p>Bioorganic &amp; Medicinal Chemistry Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, <a href=\"https:\/\/www.ambeed.com\/products\/19959-71-8.html\">Application In Synthesis of  19959-71-8<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bioorganic &amp; Medicinal Chemistry Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, <a href=\"https:\/\/www.ambeed.com\/products\/19959-71-8.html\">Application In Synthesis of  19959-71-8<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[803,131],"tags":[732],"class_list":["post-11565","post","type-post","status-publish","format-standard","hentry","category-19959-71-8","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Davoren, Jennifer E.&#039;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Davoren, Jennifer E.&#039;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-29T20:43:00+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565\",\"name\":\"Davoren, Jennifer E.'s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-29T20:43:00+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11565#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Davoren, Jennifer E.&#8217;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Davoren, Jennifer E.'s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives","description":"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565","og_locale":"en_US","og_type":"article","og_title":"Davoren, Jennifer E.'s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives","og_description":"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-11-29T20:43:00+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565","name":"Davoren, Jennifer E.'s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-11-29T20:43:00+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic &amp; Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11565"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11565#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Davoren, Jennifer E.&#8217;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 26 | CAS: 19959-71-8"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11565"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/11565\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}