{"id":1155,"date":"2020-12-01T10:57:04","date_gmt":"2020-12-01T02:57:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1155"},"modified":"2020-12-01T10:57:04","modified_gmt":"2020-12-01T02:57:04","slug":"the-important-role-of-1-methyl-1h-pyrazole-4-carbaldehyde-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1155","title":{"rendered":"The important role of 1-Methyl-1H-pyrazole-4-carbaldehyde"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., 25016-11-9<\/a><\/p>\n

D8: (?)-3-(l-Methyl-lH-pyrazol-4-yl)acrylic acidA mixture of l-methyl-lH-pyrazole-4-carbaldehyde (13 g, 118 mmol), malonic acid (12.29 g, 118 mmol), pyridine (65 ml) and piperidine (0.234 ml, 2.361 mmol) was heated to 110 C under argon for 4h. After cooling, water(lOOml) was added, followed by aqueous ammonia (12ml) to obtain a clear solution, which was acidified to pH ~ 1 with hydrochloric acid. The precipitate was collected by filtration, washed with water and dried to obtain the title compound (7.5 g, 40.5 % yield). LCMS: rt =0.92 min, [M+H+] =153<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151,131],"tags":[126],"class_list":["post-1155","post","type-post","status-publish","format-standard","hentry","category-25016-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 1-Methyl-1H-pyrazole-4-carbaldehyde<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. 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