{"id":11543,"date":"2022-11-29T09:00:13","date_gmt":"2022-11-29T01:00:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11543"},"modified":"2022-11-29T09:00:13","modified_gmt":"2022-11-29T01:00:13","slug":"antolin-albert-a-s-team-published-research-in-acs-chemical-biology-in-10-cas-71203-35-5-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11543","title":{"rendered":"Antolin, Albert A.’s team published research in ACS Chemical Biology in 10 | CAS: 71203-35-5"},"content":{"rendered":"

Antolin, Albert A. published the artcileDistant Polypharmacology among MLP Chemical Probes<\/i><\/b>, Quality Control of 71203-35-5<\/a>, the publication is ACS Chemical Biology (2015), 10(2), 395-400, database is CAplus and MEDLINE.<\/p>\n

Small mols. are essential tool compounds to probe the role of proteins in biol. and advance toward more efficient therapeutics. However, they are used without a complete knowledge of their selectivity across the entire proteome, at risk of confounding their effects due to unknown off-target interactions. Current state-of-the-art computational approaches to predicting the affinity profile of small mols. offer a means to anticipate potential nonobvious selectivity liabilities of chem. probes. The application of in silico target profiling on the full set of chem. probes from the NIH Mol. Libraries Program (MLP) resulted in the identification of biol. relevant in vitro affinities for proteins distantly related to the primary targets of ML006, ML123, ML141, and ML204, helping to lower the risk of their further use in chem. biol.<\/p>\n

ACS Chemical Biology published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Quality Control of 71203-35-5<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

ACS Chemical Biology published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Quality Control of 71203-35-5<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[804,131],"tags":[785],"class_list":["post-11543","post","type-post","status-publish","format-standard","hentry","category-71203-35-5","category-pyrazoles-derivatives","tag-m-w400-450"],"yoast_head":"\nAntolin, Albert A.'s team published research in ACS Chemical Biology in 10 | CAS: 71203-35-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Antolin, Albert A. published the artcileDistant Polypharmacology among MLP Chemical Probes, Quality Control of 71203-35-5, the publication is ACS Chemical Biology (2015), 10(2), 395-400, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antolin, Albert A.'s team published research in ACS Chemical Biology in 10 | CAS: 71203-35-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Antolin, Albert A. published the artcileDistant Polypharmacology among MLP Chemical Probes, Quality Control of 71203-35-5, the publication is ACS Chemical Biology (2015), 10(2), 395-400, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-29T01:00:13+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543\",\"name\":\"Antolin, Albert A.'s team published research in ACS Chemical Biology in 10 | CAS: 71203-35-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-29T01:00:13+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Antolin, Albert A. published the artcileDistant Polypharmacology among MLP Chemical Probes, Quality Control of 71203-35-5, the publication is ACS Chemical Biology (2015), 10(2), 395-400, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11543#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Antolin, Albert A.’s team published research in ACS Chemical Biology in 10 | CAS: 71203-35-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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