{"id":11535,"date":"2022-11-29T02:07:07","date_gmt":"2022-11-28T18:07:07","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11535"},"modified":"2022-11-29T02:07:07","modified_gmt":"2022-11-28T18:07:07","slug":"ariyani-windas-team-published-research-in-scientific-reports-in-12-cas-71203-35-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11535","title":{"rendered":"Ariyani, Winda’s team published research in Scientific Reports in 12 | CAS: 71203-35-5"},"content":{"rendered":"

Ariyani, Winda published the artcileGadolinium-based contrast agent accelerates the migration of astrocyte via integrin \u03b1v\u03b23 signaling pathway<\/i><\/b>, Quality Control of 71203-35-5<\/a>, the publication is Scientific Reports (2022), 12(1), 5850, database is CAplus and MEDLINE.<\/p>\n

Gadolinium (Gd)-based contrast agents (GBCAs) are chems. injected i.v. during magnetic resonance imaging to enhance the diagnostic yield. Repeated use of GBCAs causes their deposition in the brain. Such deposition may affect various neuronal cells, including astrocytes. In this study, we examined the effect of GBCAs (Omniscan, Magnescope, Magnevist, and Gadovist) on astrocyte migration, which is critical for formation of neurons during development and maintaining brain homeostasis. All GBCAs increased cell migration and adhesion with increased actin remodelling. Knockdown of integrin \u03b1v\u03b23 by RNAi or exposure to integrin \u03b1v\u03b23 inhibitor reduced astrocyte migration. GBCAs increased phosphorylation of downstream factors of \u03b1v\u03b23, such as FAK, ERK1\/2, and Akt. The phosphorylation of all these factors were reduced by RNAi or integrin \u03b1v\u03b23 inhibitor. GBCAs also increased the phosphorylation of their downstream factor, Rac1\/cdc42, belonging to the RhoGTPases family. Coexposure to the selective RhoGTPases inhibitors, decreased the effects of GBCAs on cell migration. These findings indicate that GBCAs exert their action via integrin \u03b1v\u03b23 to activate the signaling pathway, resulting in increased astrocyte migration. Thus, the findings of the study suggest that it is important to avoid the repeated use of GBCAs to prevent adverse side effects in the brain, particularly during development.<\/p>\n

Scientific Reports published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Quality Control of 71203-35-5<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientific Reports published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Quality Control of 71203-35-5<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[804,131],"tags":[785],"class_list":["post-11535","post","type-post","status-publish","format-standard","hentry","category-71203-35-5","category-pyrazoles-derivatives","tag-m-w400-450"],"yoast_head":"\nAriyani, Winda's team published research in Scientific Reports in 12 | CAS: 71203-35-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Ariyani, Winda published the artcileGadolinium-based contrast agent accelerates the migration of astrocyte via integrin \u03b1v\u03b23 signaling pathway, Quality Control of 71203-35-5, the publication is Scientific Reports (2022), 12(1), 5850, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ariyani, Winda's team published research in Scientific Reports in 12 | CAS: 71203-35-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Ariyani, Winda published the artcileGadolinium-based contrast agent accelerates the migration of astrocyte via integrin \u03b1v\u03b23 signaling pathway, Quality Control of 71203-35-5, the publication is Scientific Reports (2022), 12(1), 5850, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-28T18:07:07+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535\",\"name\":\"Ariyani, Winda's team published research in Scientific Reports in 12 | CAS: 71203-35-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-28T18:07:07+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Ariyani, Winda published the artcileGadolinium-based contrast agent accelerates the migration of astrocyte via integrin \u03b1v\u03b23 signaling pathway, Quality Control of 71203-35-5, the publication is Scientific Reports (2022), 12(1), 5850, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11535#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ariyani, Winda’s team published research in Scientific Reports in 12 | CAS: 71203-35-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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