{"id":1152,"date":"2020-12-01T10:57:04","date_gmt":"2020-12-01T02:57:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1152"},"modified":"2020-12-01T10:57:04","modified_gmt":"2020-12-01T02:57:04","slug":"simple-exploration-of-1134-50-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1152","title":{"rendered":"Simple exploration of 1134-50-5"},"content":{"rendered":"

1134-50-5<\/a>, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.<\/p>\n

General procedure: Example 1-103 1-Phenyl-1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-ylmethyl]-amide A mixture of 3-(aminomethyl)-7-fluoro-1-(2-fluorophenyl)quinolin-4(1H)-one (intermediate H) (50 mg, 0.175 mmol), 1 -phenyl- 1H-pyrazole-4-carboxylic acid (66 mg, 0.349 mmol), bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBrOP) (112 mg, 0.24 mmol), triethylamine (53 mg, 0.524 mmol), and DMF (3 mL) was stirred at room temperature overnight. The crude material was purified by flash chromatography (12 g silica gel eluting with 100% hexanes ramped to 70% ethyl acetate in hexanes). The product 1 -phenyl- 1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fiuoro-phenyl)-4-oxo-1,4- dihydro-quinolin-3-ylmethyl]-amide (46 mg, 58%) was obtained as an off-white solid. MS calcd. for C22H14CIF2N3O2 [(M+H)+] 426.1, obsd. 426.1.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-Phenyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-Phenyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[155,131],"tags":[126],"class_list":["post-1152","post","type-post","status-publish","format-standard","hentry","category-1134-50-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 1134-50-5<\/title>\n<meta name=\"description\" content=\"1134-50-5, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of 1134-50-5\" \/>\n<meta property=\"og:description\" content=\"1134-50-5, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-01T02:57:04+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152\",\"name\":\"Simple exploration of 1134-50-5\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-12-01T02:57:04+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"1134-50-5, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1152#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Simple exploration of 1134-50-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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