{"id":11515,"date":"2022-11-28T04:26:49","date_gmt":"2022-11-27T20:26:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11515"},"modified":"2022-11-28T04:26:49","modified_gmt":"2022-11-27T20:26:49","slug":"thach-thi-dans-team-published-research-in-journal-of-the-serbian-chemical-society-in-85-cas-71203-35-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11515","title":{"rendered":"Thach, Thi-Dan&#8217;s team published research in Journal of the Serbian Chemical Society  in 85 | CAS: 71203-35-5"},"content":{"rendered":"<p>Thach, Thi-Dan published the artcile<b><i>Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/71203-35-5.html\">HPLC of Formula: 71203-35-5<\/a>,  the publication is  Journal of the Serbian Chemical Society (2020), 85(2), 155-162, database is CAplus.<\/p>\n<p>Two series of sulfonamides were synthesized from 4-hydrazinylbenzenesulfonamide as the key starting material. 1,3,5-triarylpyrazoline sulfonamides <strong>I<\/strong> [R = H, F, MeO; Ar = Ph, 4-MeC<sub>6<\/sub>H<sub>4<\/sub>, 2-HOC<sub>6<\/sub>H<sub>4<\/sub>, 4-MeOC<sub>6<\/sub>H<sub>4<\/sub>] were obtained by cyclocondensation of various chalcones in 53-64% yields, while 4-thiazolidinone derivatives <strong>II<\/strong> [Ar<sup>1<\/sup> = Ph, 4-MeC<sub>6<\/sub>H<sub>4<\/sub>, 2-HOC<sub>6<\/sub>H<sub>4<\/sub>, 4-ClC<sub>6<\/sub>H<sub>4<\/sub>, 4-MeOC<sub>6<\/sub>H<sub>4<\/sub>] were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62% yields. The synthesized compounds were characterized based on FTIR, <sup>1<\/sup>H-NMR, <sup>13<\/sup>C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. niger (MIC value at 12.5\u03bcg mL<sup>-1<\/sup>) over the reference drug.<\/p>\n<p>Journal of the Serbian Chemical Society published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C9H8O4, <a href=\"https:\/\/www.ambeed.com\/products\/71203-35-5.html\">HPLC of Formula: 71203-35-5<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal of the Serbian Chemical Society published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C9H8O4, <a href=\"https:\/\/www.ambeed.com\/products\/71203-35-5.html\">HPLC of Formula: 71203-35-5<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[804,131],"tags":[785],"class_list":["post-11515","post","type-post","status-publish","format-standard","hentry","category-71203-35-5","category-pyrazoles-derivatives","tag-m-w400-450"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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