{"id":11499,"date":"2022-11-28T04:26:49","date_gmt":"2022-11-27T20:26:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11499"},"modified":"2022-11-28T04:26:49","modified_gmt":"2022-11-27T20:26:49","slug":"thottacherry-joseph-joses-team-published-research-in-nature-communications-in-9-cas-71203-35-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11499","title":{"rendered":"Thottacherry, Joseph Jose’s team published research in Nature Communications in 9 | CAS: 71203-35-5"},"content":{"rendered":"

Thottacherry, Joseph Jose published the artcileMechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells<\/i><\/b>, HPLC of Formula: 71203-35-5<\/a>, the publication is Nature Communications (2018), 9(1), 1-14, database is CAplus and MEDLINE.<\/p>\n

Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that, among a number of endocytic processes operating simultaneously at the cell surface, a dynamin independent pathway, the CLIC\/GEEC (CG) pathway, is rapidly and specifically upregulated upon a sudden reduction of tension. Moreover, inhibition (activation) of the CG pathway results in lower (higher) membrane tension. However, alteration in membrane tension does not directly modulate CG endocytosis. This requires vinculin, a mechano-transducer recruited to focal adhesion in adherent cells. Vinculin acts by controlling the levels of a key regulator of the CG pathway, GBF1, at the plasma membrane. Thus, the CG pathway directly regulates membrane tension and is in turn controlled via a mechano-chem. feedback inhibition, potentially leading to homeostatic regulation of membrane tension in adherent cells.<\/p>\n

Nature Communications published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C20H19NO4, HPLC of Formula: 71203-35-5<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nature Communications published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C20H19NO4, HPLC of Formula: 71203-35-5<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[804,131],"tags":[785],"class_list":["post-11499","post","type-post","status-publish","format-standard","hentry","category-71203-35-5","category-pyrazoles-derivatives","tag-m-w400-450"],"yoast_head":"\nThottacherry, Joseph Jose's team published research in Nature Communications in 9 | CAS: 71203-35-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Thottacherry, Joseph Jose published the artcileMechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells, HPLC of Formula: 71203-35-5, the publication is Nature Communications (2018), 9(1), 1-14, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thottacherry, Joseph Jose's team published research in Nature Communications in 9 | CAS: 71203-35-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Thottacherry, Joseph Jose published the artcileMechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells, HPLC of Formula: 71203-35-5, the publication is Nature Communications (2018), 9(1), 1-14, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-27T20:26:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499\",\"name\":\"Thottacherry, Joseph Jose's team published research in Nature Communications in 9 | CAS: 71203-35-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-27T20:26:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Thottacherry, Joseph Jose published the artcileMechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells, HPLC of Formula: 71203-35-5, the publication is Nature Communications (2018), 9(1), 1-14, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11499#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Thottacherry, Joseph Jose’s team published research in Nature Communications in 9 | CAS: 71203-35-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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