{"id":11470,"date":"2022-11-28T04:23:43","date_gmt":"2022-11-27T20:23:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11470"},"modified":"2022-11-28T04:23:43","modified_gmt":"2022-11-27T20:23:43","slug":"richman-jeremy-g-s-team-published-research-in-journal-of-biological-chemistry-in-282-cas-890590-91-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11470","title":{"rendered":"Richman, Jeremy G.’s team published research in Journal of Biological Chemistry in 282 | CAS: 890590-91-7"},"content":{"rendered":"

Richman, Jeremy G. published the artcileNicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors<\/i><\/b>, Synthetic Route of 890590-91-7<\/a>, the publication is Journal of Biological Chemistry (2007), 282(25), 18028-18036, database is CAplus and MEDLINE.<\/p>\n

Nicotinic acid remains the most effective therapeutic agent for the treatment and prevention of atherosclerosis resulting from low high d. lipoprotein cholesterol. The therapeutic actions of nicotinic acid are mediated by GPR109A, a Gi<\/sub> protein-coupled receptor, expressed primarily on adipocytes, Langerhans cells, and macrophage. Unfortunately, a severe, cutaneous flushing side effect limits its use and patient compliance. The mechanism of high d. lipoprotein elevation is not clearly established but assumed to be influenced by an inhibition of lipolysis in the adipose. The flushing side effect appears to be mediated by the release of prostaglandin D2 from Langerhans cells in the skin. We hypothesized that the signal transduction pathways mediating the anti-lipolytic and prostaglandin D2\/flushing pathways are distinct and that agonists may be identified that are capable of selectively eliciting the therapeutic, anti-lipolytic pathway while avoiding the activation of the parallel flush-inducing pathway. We have identified a number of GPR109A pyrazole agonists that are capable of fully inhibiting lipolysis in vitro and in vivo and not only fail to elicit a flushing response but can antagonize the ability of nicotinic acid to elicit a flush response in vivo. In contrast to flushing agonists, exposure of cells expressing GPR109A to the non-flushing agonists fails to induce internalization of the receptor or to activate ERK 1\/2 mitogen-activated protein kinase phosphorylation.<\/p>\n

Journal of Biological Chemistry published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Synthetic Route of 890590-91-7<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal of Biological Chemistry published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Synthetic Route of 890590-91-7<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[800,131],"tags":[717],"class_list":["post-11470","post","type-post","status-publish","format-standard","hentry","category-890590-91-7","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nRichman, Jeremy G.'s team published research in Journal of Biological Chemistry in 282 | CAS: 890590-91-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Richman, Jeremy G. published the artcileNicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors, Synthetic Route of 890590-91-7, the publication is Journal of Biological Chemistry (2007), 282(25), 18028-18036, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Richman, Jeremy G.'s team published research in Journal of Biological Chemistry in 282 | CAS: 890590-91-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Richman, Jeremy G. published the artcileNicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors, Synthetic Route of 890590-91-7, the publication is Journal of Biological Chemistry (2007), 282(25), 18028-18036, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-27T20:23:43+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470\",\"name\":\"Richman, Jeremy G.'s team published research in Journal of Biological Chemistry in 282 | CAS: 890590-91-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-27T20:23:43+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Richman, Jeremy G. published the artcileNicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors, Synthetic Route of 890590-91-7, the publication is Journal of Biological Chemistry (2007), 282(25), 18028-18036, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11470#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Richman, Jeremy G.’s team published research in Journal of Biological Chemistry in 282 | CAS: 890590-91-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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