{"id":11443,"date":"2022-11-25T10:27:25","date_gmt":"2022-11-25T02:27:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11443"},"modified":"2022-11-25T10:27:25","modified_gmt":"2022-11-25T02:27:25","slug":"jain-ramas-team-published-research-in-journal-of-medicinal-chemistry-in-58-cas-724710-02-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11443","title":{"rendered":"Jain, Rama’s team published research in Journal of Medicinal Chemistry in 58 | CAS: 724710-02-5"},"content":{"rendered":"

Jain, Rama published the artcileDiscovery of Potent and Selective RSK Inhibitors as Biological Probes<\/i><\/b>, Related Products of pyrazoles-derivatives<\/a>, the publication is Journal of Medicinal Chemistry (2015), 58(17), 6766-6783, database is CAplus and MEDLINE.<\/p>\n

While the p90 ribosomal S6 kinase (RSK) family has been implicated in multiple tumor cell functions, the full understanding of this kinase family has been restricted by the lack of highly selective inhibitors. A bis-phenol pyrazole was identified from high-throughput screening as an inhibitor of the N-terminal kinase of RSK2. Structure-based drug design using crystallog., conformational anal., and scaffold morphing resulted in highly optimized difluorophenol pyridine inhibitors of the RSK kinase family as demonstrated cellularly by the inhibition of YB1 phosphorylation. These compounds provide for the first time in vitro tools with an improved selectivity and potency profile to examine the importance of RSK signaling in cancer cells and to fully evaluate RSK as a therapeutic target.<\/p>\n

Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[801,131],"tags":[732],"class_list":["post-11443","post","type-post","status-publish","format-standard","hentry","category-724710-02-5","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nJain, Rama's team published research in Journal of Medicinal Chemistry in 58 | CAS: 724710-02-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Jain, Rama published the artcileDiscovery of Potent and Selective RSK Inhibitors as Biological Probes, Related Products of pyrazoles-derivatives, the publication is Journal of Medicinal Chemistry (2015), 58(17), 6766-6783, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jain, Rama's team published research in Journal of Medicinal Chemistry in 58 | CAS: 724710-02-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Jain, Rama published the artcileDiscovery of Potent and Selective RSK Inhibitors as Biological Probes, Related Products of pyrazoles-derivatives, the publication is Journal of Medicinal Chemistry (2015), 58(17), 6766-6783, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-25T02:27:25+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443\",\"name\":\"Jain, Rama's team published research in Journal of Medicinal Chemistry in 58 | CAS: 724710-02-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-25T02:27:25+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Jain, Rama published the artcileDiscovery of Potent and Selective RSK Inhibitors as Biological Probes, Related Products of pyrazoles-derivatives, the publication is Journal of Medicinal Chemistry (2015), 58(17), 6766-6783, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11443#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jain, Rama’s team published research in Journal of Medicinal Chemistry in 58 | CAS: 724710-02-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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