{"id":11383,"date":"2022-11-24T03:06:45","date_gmt":"2022-11-23T19:06:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11383"},"modified":"2022-11-24T03:06:45","modified_gmt":"2022-11-23T19:06:45","slug":"koike-eijis-team-published-research-in-nippon-kagaku-kaishi-1921-47-in-ind-chem-sect-57-cas-14580-22-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11383","title":{"rendered":"Koike, Eiji’s team published research in Nippon Kagaku Kaishi (1921-47) in Ind. Chem. Sect. 57 | CAS: 14580-22-4"},"content":{"rendered":"

Koike, Eiji published the artcileOrganic pigments. II. Syntheses of 1-phenyl-3-methyl-5-pyrazolone and its derivatives<\/i><\/b>, Application In Synthesis of 14580-22-4<\/a>, the publication is Nippon Kagaku Kaishi (1921-47) (1954), 56-8, database is CAplus.<\/p>\n

cf. C.A. 48, 6388d, 11079a. Phenylhydrazine (I) (24 g.) was added within 30 min. to a mixture of 12 g. 60% EtOH and 29.2 g. AcCH2<\/sub>CO2<\/sub>Et (II) below 50\u63b3, stirred for 2 hrs., then refluxed 4 hrs. and filtered to yield 35.5 g. of 1-phenyl-3-methyl-5-pyrazolone, m. 125.0-126.5\u63b3. The treatment of 6.5 g. p-ClC6<\/sub>H4<\/sub>NHNH2<\/sub>.HCl in H2<\/sub>O, acidified with AcOH with 4.8 g. II gave 84% 1-(p-chlorophenyl)-3-methyl-5-pyrazolone, m. 165-6\u63b3. Similarly were prepared the following analogs of III (1-substituent, m.p., % yield given): \u6170-ClC6<\/sub>H4<\/sub>, 182-3\u63b3, 68.6; m-ClC6<\/sub>H4<\/sub>, 124-5.5\u63b3, 93.6; \u6170-MeC6<\/sub>H4<\/sub>, 180-1\u63b3, 26.6; m-MeC6<\/sub>H4<\/sub>, 104.7-5.0\u63b3, 48; p-MeC6<\/sub>H4<\/sub>, 91.5-3.5\u63b3, 43.6; p-MeOC6<\/sub>H4<\/sub>, 122-3\u63b3, 36.7; m-O2<\/sub>NC6<\/sub>H4<\/sub>, 185\u63b3, 68.5; p-O2<\/sub>NC6<\/sub>H4<\/sub>, 220\u63b3, 80; m-HO3<\/sub>SC6<\/sub>H4<\/sub>, 200\u63b3, 90.8. AcCH2<\/sub>CN (42 g.) in 54 cc. H3<\/sub>O and 16 cc. concentrated HCl treated with 54 g. I in 200 cc. H2<\/sub>O and 41 cc. HCl at 35-40\u63b3, and further addition of 30 cc. concentrated HCl at 90\u63b3 gave 62.5 g. of 1-phenyl-3-methyl-5-aminopyrazole, m. 110-111.5\u63b3.<\/p>\n

Nippon Kagaku Kaishi (1921-47) published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Application In Synthesis of 14580-22-4<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nippon Kagaku Kaishi (1921-47) published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Application In Synthesis of 14580-22-4<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[799,131],"tags":[716],"class_list":["post-11383","post","type-post","status-publish","format-standard","hentry","category-14580-22-4","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nKoike, Eiji's team published research in Nippon Kagaku Kaishi (1921-47) in Ind. Chem. Sect. 57 | CAS: 14580-22-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Koike, Eiji published the artcileOrganic pigments. II. 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