{"id":11347,"date":"2022-11-23T07:29:08","date_gmt":"2022-11-22T23:29:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11347"},"modified":"2022-11-23T07:29:08","modified_gmt":"2022-11-22T23:29:08","slug":"lee-jongkooks-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-22-cas-724710-02-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11347","title":{"rendered":"Lee, Jongkook&#8217;s team published research in Bioorganic &amp; Medicinal Chemistry Letters  in 22 | CAS: 724710-02-5"},"content":{"rendered":"<p>Lee, Jongkook published the artcile<b><i>Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/724710-02-5.html\">Related Products of pyrazoles-derivatives<\/a>,  the publication is  Bioorganic &amp; Medicinal Chemistry Letters (2012), 22(12), 4044-4048, database is CAplus and MEDLINE.<\/p>\n<p>A series of hydroxybenzoxazole derivatives, e.g., <strong>I<\/strong> [R<sup>2<\/sup> = H, Cl, MeNH, MeCONH, R<sup>3<\/sup> = H, MeCO, Me(OH)CH, 3-pyrazolyl, etc., R<sup>4<\/sup> = H, 2-pyridinyl, 4-MeOC<sub>6<\/sub>H<sub>4<\/sub>, Me<sub>2<\/sub>CHNH], was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety.<\/p>\n<p>Bioorganic &amp; Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, <a href=\"https:\/\/www.ambeed.com\/products\/724710-02-5.html\">Related Products of pyrazoles-derivatives<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bioorganic &amp; Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, <a href=\"https:\/\/www.ambeed.com\/products\/724710-02-5.html\">Related Products of pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11347","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lee, Jongkook&#039;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 22 | CAS: 724710-02-5 | pyrazoles-derivatives<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11347\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lee, Jongkook&#039;s team published research in Bioorganic &amp; Medicinal Chemistry Letters in 22 | CAS: 724710-02-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Bioorganic &amp; Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Related Products of pyrazoles-derivatives.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11347\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-22T23:29:08+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11347\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11347\",\"name\":\"Lee, Jongkook's team published research in Bioorganic &amp; 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