{"id":11340,"date":"2022-11-23T07:29:08","date_gmt":"2022-11-22T23:29:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340"},"modified":"2022-11-23T07:29:08","modified_gmt":"2022-11-22T23:29:08","slug":"ambati-srinivasa-raos-team-published-research-in-journal-of-heterocyclic-chemistry-in-54-cas-724710-02-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340","title":{"rendered":"Ambati, Srinivasa Rao’s team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5"},"content":{"rendered":"

Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents<\/i><\/b>, Related Products of pyrazoles-derivatives<\/a>, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.<\/p>\n

A series of 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one derivatives was efficiently synthesized by straightforward sequential reactions. Tandem Vilsmeier Hack reaction\/cyclization\/bromination\/Suzuki cross-coupling reactions were successfully applied to the preparation of title compounds in good-to-high yields. In the synthetic sequences, 3-chloro-3-(2-oxo-2H-chromen-3-yl)acrylaldehydes react with ammonium thiocyanate to yield the corresponding 3-(isothiazol-5-yl)-2H-chromen-2-ones. These derivatives were brominated with N-bromo succinamide to yield the corresponding regioselective 3-(4-bromoisothiazol-5-yl)-2H-chromen-2-one. Finally, compound 3-(4-bromoisothiazol-5-yl)-2H-chromen-2-one was treated with various phenyl\/pyrazole\/7H-pyrrolo[2,3-d]pyrimidinyl boronic acids in the presence of K2<\/sub>CO3<\/sub> and Pd catalyst in DMF to yield the corresponding title derivatives All the synthesized compounds were characterized by anal. and spectral studies. All the final compounds were screened against different cancer cell lines (A549, PC3, SKOV3, and B16F10), and among these compounds, 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one, 6-bromo-3-(4-(4-chlorophenyl)isothiazol-5-yl)2H-chromen-2-one, 6-bromo-3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one , and 3-(4-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)isothiazole-5-yl)-6-bromo-2H-chromen-2-one displayed moderate cytotoxic activity against the tested cell lines.<\/p>\n

Journal of Heterocyclic Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal of Heterocyclic Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Related Products of pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[801,131],"tags":[732],"class_list":["post-11340","post","type-post","status-publish","format-standard","hentry","category-724710-02-5","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nAmbati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ambati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-22T23:29:08+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340\",\"name\":\"Ambati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-22T23:29:08+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11340#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ambati, Srinivasa Rao’s team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ambati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives","description":"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340","og_locale":"en_US","og_type":"article","og_title":"Ambati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives","og_description":"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-11-22T23:29:08+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340","name":"Ambati, Srinivasa Rao's team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-11-22T23:29:08+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Ambati, Srinivasa Rao published the artcileFacile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents, Related Products of pyrazoles-derivatives, the publication is Journal of Heterocyclic Chemistry (2017), 54(4), 2333-2341, database is CAplus.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=11340"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=11340#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Ambati, Srinivasa Rao’s team published research in Journal of Heterocyclic Chemistry in 54 | CAS: 724710-02-5"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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