{"id":1134,"date":"2020-11-27T13:21:49","date_gmt":"2020-11-27T05:21:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1134"},"modified":"2020-11-27T13:21:49","modified_gmt":"2020-11-27T05:21:49","slug":"a-new-synthetic-route-of-1h-pyrazol-4-ylmethanol-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1134","title":{"rendered":"A new synthetic route of (1H-Pyrazol-4-yl)methanol"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., 25222-43-9<\/a><\/p>\n

6-(2,2-Diphenyl-ethylamino)-9-((lR,4S)-4-ethoxycarbonyloxy-cyclopent-2-enyl)-9H-purine-2- carboxylic acid methyl ester (4.91 g, 9.3 mmol), (lH-Pyrazol-4-yl)-methanol (1.0 g, 10.2 mmol) and PhyP (0.73 g, 2.8 mmol) are dissolved in dry, deoxygenated tetrahydrofuran under EPO argon. Pd2(dba)3 (0.85 g, 0.93 mmol) is added to the reaction mixture. The reaction mixture is heated at 45\u00a1\u00e3 C for 1 hour. The solvent is removed in vacuo. The title material is obtained by flash column chromatography (silica, eluent 0percent MeOH to 3percent MeOH in DCM) (MH+ 536.42).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,131],"tags":[145],"class_list":["post-1134","post","type-post","status-publish","format-standard","hentry","category-25222-43-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new synthetic route of (1H-Pyrazol-4-yl)methanol<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., 25222-43-9\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1134\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of (1H-Pyrazol-4-yl)methanol\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of (1H-Pyrazol-4-yl)methanol","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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