{"id":11305,"date":"2022-11-22T04:57:56","date_gmt":"2022-11-21T20:57:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11305"},"modified":"2022-11-22T04:57:56","modified_gmt":"2022-11-21T20:57:56","slug":"miki-yasuyoshi-et-al-published-their-research-in-heterocycles-in-1996-cas-141032-72-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11305","title":{"rendered":"Miki, Yasuyoshi et al. published their research in Heterocycles in 1996 | CAS: 141032-72-6"},"content":{"rendered":"<p>Synthesis of 1-isopropylamino-3-(pyrazolo[1,5-a]pyridyloxy)-2-propanols was written by Miki, Yasuyoshi;Tasaka, Junko;Uemura, Kyoko;Miyazeki, Kunihiro;Yamada, Jun. And the article was included in Heterocycles in 1996.<a href=\"https:\/\/www.ambeed.com\/products\/141032-72-6.html\">Application of 141032-72-6<\/a> The following contents are mentioned in the article:<\/p>\n<p>Treatment of the 4-hydroxypyrazolo[1,5-a]pyridine with glycidyl tosylate in the presence of base, followed by reaction with isopropylamine gave 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-4-yloxy)-2-propanol. In a similar manner, 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-6- and 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-3-yloxy)-2-propanol were also prepared This study involved multiple reactions and reactants, such as Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6<a href=\"https:\/\/www.ambeed.com\/products\/141032-72-6.html\">Application of 141032-72-6<\/a>).<\/p>\n<p>Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/141032-72-6.html\">Application of 141032-72-6<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/141032-72-6.html\">Application of 141032-72-6<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[788,131],"tags":[128],"class_list":["post-11305","post","type-post","status-publish","format-standard","hentry","category-141032-72-6","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Miki, Yasuyoshi et al. published their research in Heterocycles in 1996 | CAS: 141032-72-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis of 1-isopropylamino-3-(pyrazolo[1,5-a]pyridyloxy)-2-propanols was written by Miki, Yasuyoshi;Tasaka, Junko;Uemura, Kyoko;Miyazeki, Kunihiro;Yamada, Jun. 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