{"id":11291,"date":"2022-11-22T04:56:43","date_gmt":"2022-11-21T20:56:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11291"},"modified":"2022-11-22T04:56:43","modified_gmt":"2022-11-21T20:56:43","slug":"fan-xue-min-et-al-published-their-research-in-asian-journal-of-organic-chemistry-in-2016-cas-17355-75-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11291","title":{"rendered":"Fan, Xue-Min et al. published their research in Asian Journal of Organic Chemistry in 2016 | CAS: 17355-75-8"},"content":{"rendered":"<p>Pd-Catalyzed Late-Stage Monoacetoxylation and Monoiodination of 4-Alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via Direct Csp<sup>2<\/sup>-H Bond Activation was written by Fan, Xue-Min;Guo, Ying;Li, Yu-Dan;Yu, Kun-Kun;Liu, Hong-Wei;Liao, Dao-Hua;Ji, Ya-Fei. And the article was included in Asian Journal of Organic Chemistry in 2016.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">HPLC of Formula: 17355-75-8<\/a> The following contents are mentioned in the article:<\/p>\n<p>A palladium-catalyzed, late-stage functionalization of 4-alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates to achieve acetoxylation or iodination via Csp<sup>2<\/sup>-H bond activation with synthetically useful to excellent yields was described. These straightforward transformations featured highly functionalized substrates, excellent site selectivity, rapid reaction and simple operation. The C-O and C-I bond-forming protocols allowed convenient accesses to lots of complex monoacetoxylated and monoiodinated products from pharmaceutically important intermediates. Iodoacetic acid was also used as the iodinating agent in C-H bond activation. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">HPLC of Formula: 17355-75-8<\/a>).<\/p>\n<p>Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">HPLC of Formula: 17355-75-8<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">HPLC of Formula: 17355-75-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[786,131],"tags":[129],"class_list":["post-11291","post","type-post","status-publish","format-standard","hentry","category-17355-75-8","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fan, Xue-Min et al. published their research in Asian Journal of Organic Chemistry in 2016 | CAS: 17355-75-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pd-Catalyzed Late-Stage Monoacetoxylation and Monoiodination of 4-Alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via Direct Csp2-H Bond Activation was written by Fan, Xue-Min;Guo, Ying;Li, Yu-Dan;Yu, Kun-Kun;Liu, Hong-Wei;Liao, Dao-Hua;Ji, Ya-Fei. 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