{"id":11284,"date":"2022-11-22T04:56:43","date_gmt":"2022-11-21T20:56:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11284"},"modified":"2022-11-22T04:56:43","modified_gmt":"2022-11-21T20:56:43","slug":"martins-marcos-a-p-et-al-published-their-research-in-journal-of-heterocyclic-chemistry-in-1999-cas-17355-75-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11284","title":{"rendered":"Martins, Marcos A. P. et al. published their research in Journal of Heterocyclic Chemistry in 1999 | CAS: 17355-75-8"},"content":{"rendered":"<p>Haloacetylated enol ethers. 11. Synthesis of 1-methyl- and 1-phenyl pyrazole-3(5)-ethyl esters. A one-pot procedure was written by Martins, Marcos A. P.;Freitag, Rogerio A.;Da Rosa, Adriano;Flores, Alex F. C.;Zanatta, Nilo;Bonacorso, Helio G.. And the article was included in Journal of Heterocyclic Chemistry in 1999.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">Product Details of 17355-75-8<\/a> The following contents are mentioned in the article:<\/p>\n<p>Me and phenylpyrazole Et esters <strong>I<\/strong> [R = Me, Ph; R<sup>1<\/sup> = Me, Ph, EtO<sub>2<\/sub>C; R<sup>2<\/sup> = H, Me; R<sup>1<\/sup>R<sup>2<\/sup> = (CH<sub>2<\/sub>)<sub>4<\/sub>; R<sup>3<\/sup> = EtO<sub>2<\/sub>C, Me, Ph; R<sup>2<\/sup>R<sup>3<\/sup> = (CH<sub>2<\/sub>)<sub>4<\/sub>] are prepared by the cyclocondensation of \u03b2-alkoxyvinyl trichloromethyl ketones <strong>II<\/strong> [R<sup>4<\/sup> = Me, Et; R<sup>5<\/sup> = Me, Ph; R<sup>6<\/sup> = H, Me; R<sup>5<\/sup>R<sup>6<\/sup> = (CH<sub>2<\/sub>)<sub>4<\/sub>] with Me and Ph hydrazine hydrochloride in a one-pot reaction under mild conditions in 60-89% with a variety of enol ethers. Effects of hydrazine and \u03b2-alkoxyvinyl trichloromethyl ketone substituents on the regiochem. of pyrazole cyclization were observed This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">Product Details of 17355-75-8<\/a>).<\/p>\n<p>Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">Product Details of 17355-75-8<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/17355-75-8.html\">Product Details of 17355-75-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[786,131],"tags":[129],"class_list":["post-11284","post","type-post","status-publish","format-standard","hentry","category-17355-75-8","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Martins, Marcos A. 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