{"id":11280,"date":"2022-11-22T04:55:21","date_gmt":"2022-11-21T20:55:21","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11280"},"modified":"2022-11-22T04:55:21","modified_gmt":"2022-11-21T20:55:21","slug":"vartanyan-l-s-et-al-published-their-research-in-khimiko-farmatsevticheskii-zhurnal-in-1982-cas-49834-67-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11280","title":{"rendered":"Vartanyan, L. S. et al. published their research in Khimiko-Farmatsevticheskii Zhurnal in 1982 | CAS: 49834-67-5"},"content":{"rendered":"<p>New xanthine oxidase inhibitors of the pyrazolo[3,4-d]pyrimidine and pyrazolo[3,4-b]pyridine class. II. Comparative evaluation of their effectiveness was written by Vartanyan, L. S.;Rashba, Yu. E.;Kazachenko, A. I.;Korbukh, I. A.;Bulychev, Yu. N.;Preobrazhenskaya, M. N.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1982.<a href=\"https:\/\/www.ambeed.com\/products\/49834-67-5.html\">Reference of 49834-67-5<\/a> The following contents are mentioned in the article:<\/p>\n<p>Thirty pyrazolo[3,4-d]pyrimidines <strong>I<\/strong> (R = H, CH<sub>2<\/sub>NMe<sub>2<\/sub>, <em>N<\/em>-methylpiperazinylmethyl, or piperidinylmethyl; R<sup>1<\/sup> = H, CH<sub>2<\/sub>NEt<sub>2<\/sub>, or <em>N<\/em>-methylpiperazinylmethyl; R<sup>2<\/sup> = H or Me) and <strong>II<\/strong> [R = H, CN, CH<sub>2<\/sub>CN, C(NH<sub>2<\/sub>):NOH, etc.; R<sup>1<\/sup> = SH, SMe, NHNH<sub>2<\/sub>, etc.; R<sup>2<\/sup> = H, SH, or SMe] and 5 pyrazolo[3,4-b]pyridines <strong>III<\/strong> (R = H or OH; R<sup>1<\/sup> = H, OH, SH, Cl, or SMe) were tested for <em>xanthine<\/em>\u00a0<em>oxidase<\/em>\u00a0\u00a0<strong>[9002-17-9]<\/strong>-inhibiting activity. The kinetics of xanthine oxidase inhibition by <strong>I<\/strong>, <strong>II<\/strong>, and <strong>III<\/strong> was studied. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5<a href=\"https:\/\/www.ambeed.com\/products\/49834-67-5.html\">Reference of 49834-67-5<\/a>).<\/p>\n<p>1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/49834-67-5.html\">Reference of 49834-67-5<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/49834-67-5.html\">Reference of 49834-67-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[793,131],"tags":[128],"class_list":["post-11280","post","type-post","status-publish","format-standard","hentry","category-49834-67-5","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vartanyan, L. S. et al. published their research in Khimiko-Farmatsevticheskii Zhurnal in 1982 | CAS: 49834-67-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"New xanthine oxidase inhibitors of the pyrazolo[3,4-d]pyrimidine and pyrazolo[3,4-b]pyridine class. II. Comparative evaluation of their effectiveness was written by Vartanyan, L. S.;Rashba, Yu. E.;Kazachenko, A. I.;Korbukh, I. A.;Bulychev, Yu. N.;Preobrazhenskaya, M. N.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1982.Reference of 49834-67-5 The following contents are mentioned in the article:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11280\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vartanyan, L. S. et al. published their research in Khimiko-Farmatsevticheskii Zhurnal in 1982 | CAS: 49834-67-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"New xanthine oxidase inhibitors of the pyrazolo[3,4-d]pyrimidine and pyrazolo[3,4-b]pyridine class. II. 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