{"id":11236,"date":"2022-11-21T05:06:50","date_gmt":"2022-11-20T21:06:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11236"},"modified":"2022-11-21T05:06:50","modified_gmt":"2022-11-20T21:06:50","slug":"bryan-marian-c-s-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-23-cas-724710-02-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11236","title":{"rendered":"Bryan, Marian C.’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 724710-02-5"},"content":{"rendered":"

Bryan, Marian C. published the artcileN-substituted azaindoles as potent inhibitors of Cdc7 kinase<\/i><\/b>, Category: pyrazoles-derivatives<\/a>, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2056-2060, database is CAplus and MEDLINE.<\/p>\n

Cdc7 kinase is responsible for the initiation and regulation of DNA replication and was proposed as a target for cancer therapy. We have identified a class of Cdc7 inhibitors based on a substituted indole core. Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36). In parallel, quantum mech. conformational anal. helped to rationalize SAR observations, led to a proposal of the preferred binding conformation in the absence of co-crystallog. data, and allowed the design of 7-azaindole 37 as a second lead in this series.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[732],"class_list":["post-11236","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nBryan, Marian C.'s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 724710-02-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Bryan, Marian C. published the artcileN-substituted azaindoles as potent inhibitors of Cdc7 kinase, Category: pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2056-2060, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bryan, Marian C.'s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 724710-02-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Bryan, Marian C. published the artcileN-substituted azaindoles as potent inhibitors of Cdc7 kinase, Category: pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2056-2060, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T21:06:50+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236\",\"name\":\"Bryan, Marian C.'s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 724710-02-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T21:06:50+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Bryan, Marian C. published the artcileN-substituted azaindoles as potent inhibitors of Cdc7 kinase, Category: pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2056-2060, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11236#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Bryan, Marian C.’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 724710-02-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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