{"id":11229,"date":"2022-11-21T05:06:50","date_gmt":"2022-11-20T21:06:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11229"},"modified":"2022-11-21T05:06:50","modified_gmt":"2022-11-20T21:06:50","slug":"girimanchanaika-swamy-savvemalas-team-published-research-in-international-journal-of-molecular-sciences-in-22-cas-763120-58-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11229","title":{"rendered":"Girimanchanaika, Swamy Savvemala’s team published research in International Journal of Molecular Sciences in 22 | CAS: 763120-58-7"},"content":{"rendered":"

Girimanchanaika, Swamy Savvemala published the artcileInvestigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells<\/i><\/b>, SDS of cas: 763120-58-7<\/a>, the publication is International Journal of Molecular Sciences (2021), 22(20), 11002, database is CAplus and MEDLINE.<\/p>\n

The design and development of a small mol. named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which specifically inhibited the phosphorylation of BAD at Ser99 in human carcinoma cells has been previously reported. Herein, the synthesis, characterization, and effect on cancer cell viability of NPB analogs, and the single-crystal X-ray crystallog. studies of an example compound (4r), which was grown via slow-solvent evaporation technique is reported. Screening for loss of viability in mammary carcinoma cells revealed that compounds such as 2[4(2,3-dichlorophenyl)piperazin-1-yl][naphthalen-1-yl]methylphenol (4e), 5[4(2,3-dichlorophenyl)piperazin-1-yl](2-hydroxyphenyl)methyluran-2-carbaldehyde (4f), 3[2-hydroxyphenyl][4(p-tolyl)piperazin-1-ylmethyl]benzaldehyde (4i), and NPB inhibited the viability of MCF-7 cells with IC50<\/sub> values of 5.90, 3.11, 7.68, and 6.5 \u03bcM, resp. The loss of cell viability was enhanced by the NPB analogs synthesized by adding newer rings such as naphthalene and furan-2-carbaldehyde in place of N-cyclopentyl-benzamide of NPB. Furthermore, these compounds decreased Ser99 phosphorylation of hBAD. Addnl. in silico d. functional theory calculations suggested possibilities for other analogs of NPB that may be more suitable for further development.<\/p>\n

International Journal of Molecular Sciences published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, SDS of cas: 763120-58-7<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

International Journal of Molecular Sciences published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, SDS of cas: 763120-58-7<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[732],"class_list":["post-11229","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nGirimanchanaika, Swamy Savvemala's team published research in International Journal of Molecular Sciences in 22 | CAS: 763120-58-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Girimanchanaika, Swamy Savvemala published the artcileInvestigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells, SDS of cas: 763120-58-7, the publication is International Journal of Molecular Sciences (2021), 22(20), 11002, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Girimanchanaika, Swamy Savvemala's team published research in International Journal of Molecular Sciences in 22 | CAS: 763120-58-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Girimanchanaika, Swamy Savvemala published the artcileInvestigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells, SDS of cas: 763120-58-7, the publication is International Journal of Molecular Sciences (2021), 22(20), 11002, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T21:06:50+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229\",\"name\":\"Girimanchanaika, Swamy Savvemala's team published research in International Journal of Molecular Sciences in 22 | CAS: 763120-58-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T21:06:50+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Girimanchanaika, Swamy Savvemala published the artcileInvestigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells, SDS of cas: 763120-58-7, the publication is International Journal of Molecular Sciences (2021), 22(20), 11002, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11229#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Girimanchanaika, Swamy Savvemala’s team published research in International Journal of Molecular Sciences in 22 | CAS: 763120-58-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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