{"id":1122,"date":"2020-11-26T11:10:37","date_gmt":"2020-11-26T03:10:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1122"},"modified":"2020-11-26T11:10:37","modified_gmt":"2020-11-26T03:10:37","slug":"introduction-of-a-new-synthetic-route-about-82560-12-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1122","title":{"rendered":"Introduction of a new synthetic route about 82560-12-1"},"content":{"rendered":"

82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 82560-12-1<\/a><\/p>\n

lution of Intermediate 11a (444 mg, 1.9 mmol), 3-tert-butyl- lH- pyrazole-5-amine (312 mg, 2.2 mmol) and trans-N,N’-dimethyl-cyclohexane- diamine (53.0 mg, 0.4 mmol) was formed in toluene (5 mL). Potassium carbonate (543 mg, 3.9 mmol) was added and the mixture degassed by bubbling nitrogen through it. Copper(I) iodide (36.0 mg, 0.2 mmol) was added and the mixture was sealed in a microwave vial and heated under microwave irradiation at 150C for 2 h. The resulting mixture was partitioned between EtOAc\/Water and extracted with EtOAc. The combined organics were dried over Na2SO4, filtered and evaporated. Purification by FCC, eluting with a gradient of 25-100% EtOAc in cyclohexane, gave the title compound (200 mg, 43%). LCMS (Method 3): Rt 2.30 min, m\/z 250 [MH+].<\/p>\n

Statistics shows that 82560-12-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-tert-butylpyrazole.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 82560-12-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-tert-butylpyrazole.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[142,131],"tags":[126],"class_list":["post-1122","post","type-post","status-publish","format-standard","hentry","category-82560-12-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 82560-12-1<\/title>\n<meta name=\"description\" content=\"82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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