{"id":11177,"date":"2022-11-21T05:02:08","date_gmt":"2022-11-20T21:02:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11177"},"modified":"2022-11-21T05:02:08","modified_gmt":"2022-11-20T21:02:08","slug":"qiao-lixins-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-19-cas-137837-55-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11177","title":{"rendered":"Qiao, Lixin’s team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 137837-55-9"},"content":{"rendered":"

Qiao, Lixin published the artcileStructure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors<\/i><\/b>, Application of Pyrazolo[1,5-a]pyridin-3-amine<\/a>, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6122-6126, database is CAplus and MEDLINE.<\/p>\n

A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a Ph or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structure-activity relationship for EphB3 inhibition of both heterocyclic series was similar. Kinase inhibitory activity was also demonstrated for representative analogs in cell culture. An analog (32, LDN-211904) was also profiled for inhibitory activity against a panel of 288 kinases and found to be quite selective for tyrosine kinases. Overall, these studies provide useful mol. probes for examining the in vitro, cellular and potentially in vivo kinase-dependent function of EphB3 receptor.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about 137837-55-9. 137837-55-9 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Amine, name is Pyrazolo[1,5-a]pyridin-3-amine, and the molecular formula is C7H7N3, Application of Pyrazolo[1,5-a]pyridin-3-amine<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about 137837-55-9. 137837-55-9 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Amine, name is Pyrazolo[1,5-a]pyridin-3-amine, and the molecular formula is C7H7N3, Application of Pyrazolo[1,5-a]pyridin-3-amine<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[732],"class_list":["post-11177","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nQiao, Lixin's team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 137837-55-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Qiao, Lixin published the artcileStructure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors, Application of Pyrazolo[1,5-a]pyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6122-6126, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qiao, Lixin's team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 137837-55-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Qiao, Lixin published the artcileStructure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors, Application of Pyrazolo[1,5-a]pyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6122-6126, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T21:02:08+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177\",\"name\":\"Qiao, Lixin's team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 137837-55-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T21:02:08+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Qiao, Lixin published the artcileStructure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors, Application of Pyrazolo[1,5-a]pyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6122-6126, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=11177#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Qiao, Lixin’s team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 137837-55-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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