{"id":11174,"date":"2022-11-21T05:02:08","date_gmt":"2022-11-20T21:02:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11174"},"modified":"2022-11-21T05:02:08","modified_gmt":"2022-11-20T21:02:08","slug":"skinner-philip-j-s-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-17-cas-890590-91-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11174","title":{"rendered":"Skinner, Philip J.’s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 890590-91-7"},"content":{"rendered":"

Skinner, Philip J. published the artcileFluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a<\/i><\/b>, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid<\/a>, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(20), 5620-5623, database is CAplus and MEDLINE.<\/p>\n

A series of 5-alkyl pyrazole-3-carboxylic acids, e.g., I<\/strong>, were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niacin receptor, GPR109b. A further series of 4-fluoro-5-alkyl pyrazole-3-carboxylic acids were shown to display similar potency. One example from the series was shown to have improved properties in vivo compared to niacin.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C17H14N2O2, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C17H14N2O2, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[717],"class_list":["post-11174","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nSkinner, Philip J.'s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 890590-91-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Skinner, Philip J. published the artcileFluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(20), 5620-5623, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Skinner, Philip J.'s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 890590-91-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Skinner, Philip J. published the artcileFluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(20), 5620-5623, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T21:02:08+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174\",\"name\":\"Skinner, Philip J.'s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 890590-91-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T21:02:08+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Skinner, Philip J. published the artcileFluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(20), 5620-5623, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11174#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Skinner, Philip J.’s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 890590-91-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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