{"id":1117,"date":"2020-11-26T11:10:37","date_gmt":"2020-11-26T03:10:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1117"},"modified":"2020-11-26T11:10:37","modified_gmt":"2020-11-26T03:10:37","slug":"new-learning-discoveries-about-3-phenyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1117","title":{"rendered":"New learning discoveries about 3-Phenyl-1H-pyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2458-26-6, name is 3-Phenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., 2458-26-6<\/a><\/p>\n

3-Phenylpyrazole (2.00 g, 13.87 mmol) as a solid was added to a stirred slurry of NaH (0.33 g, 13.87 mmol) in THF (60 mL) at r.t. After 30 min SOCl2 (0.50 mL, 0.83 g, 6.94 mmol) was added in one portion via syringe and the resulting mixture stirred at r.t. for 5 min. After addition of 3,4-dihydroxybenzaldehyde (0.96 g, 6.94 mmol) and pyridine (5.60 mL, 4.78 g, 60.40 mmol), the reaction mixture was kept at reflux temperature for 16 h. H2O (50 mL) was added and the aqueous phase extracted into CH2Cl2 (3 \u00a1\u00c1 50 mL). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and the filtrate was evaporated to dryness in vacuo. The crude product was purified by column chromatography (silica gel; CHCl3\/EtOAc 1:1). All product-containing fractions were concentrated by rotary evaporation at 40 C and upon cooling to r.t. colorless 1(Ph) precipitated, which was isolated by filtration and washed with Et2O. Yield: 1.53 g (54%). Rf = 0.63 (silica gel, CHCl3\/EtOAc 1:1). 1H NMR (400.1 MHz, d6-DMSO) delta = 6.48 (dd, 3JHH = 8.3, 4JHH = 2.0, 1 H; HQ-H6), 6.66 (d, 4JHH = 2.0, 1 H; HQ-H2), 6.76 (d, 3JHH = 8.3, 1 H; HQ-H5), 6.84 (d, 3JHH = 2.5, 2 H; pz-H4), 7.31 (m, 2 H; Ph-H4), 7.41 (m, 4 H; Ph-H3), 7.82 (m, 4 H; Ph-H2), 7.91 (s, 1 H; CH), 7.94 (d, 3JHH = 2.5, 2 H; pz-H5), 9.15 (bs, 2 H; OH). 13C NMR (100.6 MHz, d6-DMSO) delta = 76.7 (Cpz2), 103.5 (pz-C4), 114.4 (HQ-C2), 115.5 (HQ-C5), 118.2 (HQ-C6), 125.3 (Ph-C2), 127.2 (HQ-C1), 127.8 (Ph-C4), 128.7 (Ph-C3), 131.9 (pz-C5), 132.8 (Ph-C1), 145.3, 146.1 (HQ-C3,4), 151.0 (pz-C3). ESI-MS: m\/z (%) 263 (67) [M – Phpz]-, 408 (100) [M – H]-. Anal. Calcd (%) for C25H20N4O2 (408.45): C 73.51, H 4.94, N 13.72. Found: C 73.22, H 4.86, N 13.67.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164,131],"tags":[126],"class_list":["post-1117","post","type-post","status-publish","format-standard","hentry","category-2458-26-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 3-Phenyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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