{"id":11152,"date":"2022-11-21T05:00:35","date_gmt":"2022-11-20T21:00:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11152"},"modified":"2022-11-21T05:00:35","modified_gmt":"2022-11-20T21:00:35","slug":"anderson-niall-a-s-team-published-research-in-organic-biomolecular-chemistry-in-14-cas-1025735-46-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11152","title":{"rendered":"Anderson, Niall A.’s team published research in Organic & Biomolecular Chemistry in 14 | CAS: 1025735-46-9"},"content":{"rendered":"

Anderson, Niall A. published the artcileSynthesis and determination of absolute configuration of a non-peptidic \u03b1v<\/sub>\u03b26<\/sub> integrin antagonist for the treatment of idiopathic pulmonary fibrosis<\/i><\/b>, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid<\/a>, the publication is Organic & Biomolecular Chemistry (2016), 14(25), 5992-6009, database is CAplus and MEDLINE.<\/p>\n

A diastereoselective synthesis of I<\/strong>, a potential therapeutic agent for the treatment of idiopathic pulmonary fibrosis, which is currently undergoing Phase I trials is reported. The key steps in the synthesis involved alkylation of 2-methylnaphthyridine with (R)-N-Boc-3-(iodomethyl)-pyrrolidine, and an asym. Rh-catalyzed addition of an arylboronic acid to a 4-(N-pyrrolidinyl)crotonate ester. The overall yield of the seven linear step synthesis is 8% and the product is obtained in <99.5% ee proceeding with 80% de. The absolute configuration of I<\/strong> is established by an alternative asym. synthesis involving alkylation of an arylacetic acid using Evans oxazolidinone chem., acylation using the resulting 2-arylsuccinic acid, and reduction The absolute configuration of the benzylic asym. center is established as (S).<\/p>\n

Organic & Biomolecular Chemistry published new progress about 1025735-46-9. 1025735-46-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Benzene,Boronic Acids, name is 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid, and the molecular formula is C11H13BN2O2, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Organic & Biomolecular Chemistry published new progress about 1025735-46-9. 1025735-46-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Benzene,Boronic Acids, name is 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid, and the molecular formula is C11H13BN2O2, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[716],"class_list":["post-11152","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nAnderson, Niall A.'s team published research in Organic & Biomolecular Chemistry in 14 | CAS: 1025735-46-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Anderson, Niall A. published the artcileSynthesis and determination of absolute configuration of a non-peptidic \u03b1v\u03b26 integrin antagonist for the treatment of idiopathic pulmonary fibrosis, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid, the publication is Organic & Biomolecular Chemistry (2016), 14(25), 5992-6009, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anderson, Niall A.'s team published research in Organic & Biomolecular Chemistry in 14 | CAS: 1025735-46-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Anderson, Niall A. published the artcileSynthesis and determination of absolute configuration of a non-peptidic \u03b1v\u03b26 integrin antagonist for the treatment of idiopathic pulmonary fibrosis, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid, the publication is Organic & Biomolecular Chemistry (2016), 14(25), 5992-6009, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T21:00:35+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152\",\"name\":\"Anderson, Niall A.'s team published research in Organic & Biomolecular Chemistry in 14 | CAS: 1025735-46-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T21:00:35+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Anderson, Niall A. published the artcileSynthesis and determination of absolute configuration of a non-peptidic \u03b1v\u03b26 integrin antagonist for the treatment of idiopathic pulmonary fibrosis, Safety of 3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenylboronic acid, the publication is Organic & Biomolecular Chemistry (2016), 14(25), 5992-6009, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11152#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Anderson, Niall A.’s team published research in Organic & Biomolecular Chemistry in 14 | CAS: 1025735-46-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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