{"id":11139,"date":"2022-11-21T04:59:04","date_gmt":"2022-11-20T20:59:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11139"},"modified":"2022-11-21T04:59:04","modified_gmt":"2022-11-20T20:59:04","slug":"barraclough-pauls-team-published-research-in-archiv-der-pharmazie-weinheim-germany-in-325-cas-3553-12-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11139","title":{"rendered":"Barraclough, Paul&#8217;s team published research in Archiv der Pharmazie (Weinheim, Germany)  in 325 | CAS: 3553-12-6"},"content":{"rendered":"<p>Barraclough, Paul published the artcile<b><i>Inotropic polyazapentalene sulmazole analogs<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/3553-12-6.html\">COA of Formula: C5H7N3O<\/a>,  the publication is  Archiv der Pharmazie (Weinheim, Germany) (1992), 325(4), 225-34, database is CAplus and MEDLINE.<\/p>\n<p>Aryl substituted 1<em>H<\/em>-imidazo[1,2-<em>a<\/em>]imidazole <strong>I<\/strong>, imidazo[2,1-<em>b<\/em>]thiazole <strong>II<\/strong> (X = S), 1,4-dihydroimidazo[4,5-<em>d<\/em>]imidazole <strong>III<\/strong>, and 1(2),4-dihydroimidazo[4,5-<em>c<\/em>]pyrazoles <strong>IV<\/strong> (Y = SOMe, SMe, cyano, CONH<sub>2<\/sub>) and <strong>V<\/strong> (Z = cyano, CONH<sub>2<\/sub>) have been prepared Thus, 2-aminoimidazole reacted with 2-bromo-2&#8242;,4&#8242;-dimethoxyacetophenone to give <strong>II<\/strong> (X = NCH<sub>2<\/sub>R<sup>1<\/sup>, R<sup>1<\/sup> = 2&#8242;,4&#8242;-dimethoxybenzoyl) which was treated with Zn in aqueous HOAc to give <strong>I<\/strong> in 70% yield. An x-ray crystallog. study confirmed the structure of <strong>I<\/strong> and showed this analog to exist as the 1<em>H<\/em>-tautomer. These heterocycles were evaluated as inotropic agents and analogs <strong>IV<\/strong> (Y = SOMe, CONH<sub>2<\/sub>) and <strong>V<\/strong> (Z = CONH<sub>2<\/sub>) displayed inotropic properties which were less potent in vitro, but more potent in vivo, than those of sulmazole. Structure-activity relationships are discussed.<\/p>\n<p>Archiv der Pharmazie (Weinheim, Germany) published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, <a href=\"https:\/\/www.ambeed.com\/products\/3553-12-6.html\">COA of Formula: C5H7N3O<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,<br \/><a href=\"Pyrazole - Wikipedia\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Archiv der Pharmazie (Weinheim, Germany) published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, <a href=\"https:\/\/www.ambeed.com\/products\/3553-12-6.html\">COA of Formula: C5H7N3O<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[732],"class_list":["post-11139","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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