{"id":11123,"date":"2022-11-21T04:59:04","date_gmt":"2022-11-20T20:59:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11123"},"modified":"2022-11-21T04:59:04","modified_gmt":"2022-11-20T20:59:04","slug":"rather-imran-ibni-ganis-team-published-research-in-environmental-science-and-pollution-research-in-29-cas-71203-35-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11123","title":{"rendered":"Rather, Imran Ibni Gani’s team published research in Environmental Science and Pollution Research in 29 | CAS: 71203-35-5"},"content":{"rendered":"

Rather, Imran Ibni Gani published the artcileExploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice<\/i><\/b>, Product Details of C22H21N3O3S<\/a>, the publication is Environmental Science and Pollution Research (2022), 29(12), 17417-17424, database is CAplus and MEDLINE.<\/p>\n

The RhoA gene showed an important genotypic association with nicotine dependence and smoking initiation. The current study aims to investigate the effect of the Rho GTPase inhibitor ML141 in the progression of nicotine dependence in a mice model of precipitated nicotine withdrawal syndrome by mecamylamine. The exptl. procedure involved administration of 2.5 mg\/kg nicotine dissolved in normal saline s.c. (s.c) four times a day consecutively for 7 days and last single dose in the morning on 8th day. ML-141 was dissolved in DMSO (DMSO) and was administered daily with nicotine as corrective treatment at a dose of 1,5 and 10 mg\/kg (p < 0.05). An injection of 3 mg\/kg of mecamylamine i.p. (i.p.) was given an hour later than the last nicotine dose on the day 8 to precipitate withdrawal of nicotine and withdrawal severity was assessed by measuring hyperalgesia, piloerection, jumping frequency, tremors, and withdrawal severity score (WSS). Various behavioral changes such as hyperalgesia, piloerection, jumping frequency, and tremors were monitored and WSS was calculated ML-141 a selective Rho GTPase inhibitor was found to show dose-dependent effect on all these parameters. Inhibition of Rho GTPase was found to reduce the severity of withdrawal syndrome; therefore, it can be concluded that Rho GTPase would serve as a suitable biol. target by regulating the reward system in brain and could be used as new target for drug discovery.<\/p>\n

Environmental Science and Pollution Research published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Product Details of C22H21N3O3S<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Environmental Science and Pollution Research published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR\/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Product Details of C22H21N3O3S<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[785],"class_list":["post-11123","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w400-450"],"yoast_head":"\nRather, Imran Ibni Gani's team published research in Environmental Science and Pollution Research in 29 | CAS: 71203-35-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Rather, Imran Ibni Gani published the artcileExploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice, Product Details of C22H21N3O3S, the publication is Environmental Science and Pollution Research (2022), 29(12), 17417-17424, database is CAplus and MEDLINE.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rather, Imran Ibni Gani's team published research in Environmental Science and Pollution Research in 29 | CAS: 71203-35-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Rather, Imran Ibni Gani published the artcileExploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice, Product Details of C22H21N3O3S, the publication is Environmental Science and Pollution Research (2022), 29(12), 17417-17424, database is CAplus and MEDLINE.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-20T20:59:04+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123\",\"name\":\"Rather, Imran Ibni Gani's team published research in Environmental Science and Pollution Research in 29 | CAS: 71203-35-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-20T20:59:04+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Rather, Imran Ibni Gani published the artcileExploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice, Product Details of C22H21N3O3S, the publication is Environmental Science and Pollution Research (2022), 29(12), 17417-17424, database is CAplus and MEDLINE.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11123#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Rather, Imran Ibni Gani’s team published research in Environmental Science and Pollution Research in 29 | CAS: 71203-35-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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