{"id":11071,"date":"2022-11-21T04:54:55","date_gmt":"2022-11-20T20:54:55","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11071"},"modified":"2022-11-21T04:54:55","modified_gmt":"2022-11-20T20:54:55","slug":"lapkin-i-i-s-team-published-research-in-zhurnal-organicheskoi-khimii-in-2-cas-13599-22-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11071","title":{"rendered":"Lapkin, I. I.’s team published research in Zhurnal Organicheskoi Khimii in 2 | CAS: 13599-22-9"},"content":{"rendered":"

Lapkin, I. I. published the artcileEsters of oxo acids of acetylene series. VI. Reaction of the esters of phenylethynylglyoxalic acid with hydrazine, hydrazide, and hydroxylamine<\/i><\/b>, Product Details of C16H12N2O2<\/a>, the publication is Zhurnal Organicheskoi Khimii (1966), 2(11), 2075-8, database is CAplus.<\/p>\n

cf. CA 65, 10523b. Addition of N2H4.H2O to Et phenylethynylglyoxalate in EtOH gave 75% Et 3-phenylpyrazole-5-carboxylate, m. 139.5\u00b0; similarly were prepared: Pr ester, m. 110\u00b0; iso-Pr ester, m. 164\u00b0. Addition of RNHNH2 in Et2O to the appropriate ester of phenylethynylglyoxalic acid gave the following esters of 4-arylhydrazino-4-phenyl-3-buten-2-on-1-oic acids, RNHNHCPh:CCOCO2R’ (R and R’ shown, resp.): Ph, Et, 32%, m. 83\u00b0; Ph, iso-Pr (I) 65%, m. 124.5\u00b0; p-MeC6H4, iso-Pr, 32%, m. 77\u00b0; 0-MeC6H4, iso-Pr, 55%, m. 72.5\u00b0; Bz, iso-Pr (II) 87%, m. 125.5\u00b0; 0-O2NC6H4CO, iso-Pr, 78%, m. 137\u00b0; m-O2NC6H4CO, iso-Pr, 83%, m. 181\u00b0; p-O2NC6H4CO, iso-Pr, 88%, m. 175\u00b0. II heated in AcOH 2 hrs. gave 93% 1,5-diphenylpyrazole-3-carboxylic acid iso-Pr ester, m. 86.5-7\u00b0. I heated with aqueous alc. KOH 20 min. gave 1,5-diphenylpyrazole-3-carboxylic acid. Heating iso-Pr phenylethynylglyoxalate with HONH2.HCl in aqueous EtOH gave after addition of aqueous Na2CO3 over 9 hrs. 50% iso-Pr 3-phenylisoxazole-5-carboxylate, m. 65-6\u00b0. Similarly was prepared 29% Et 3-phenylisoxazole-5-carboxylate, m. 47\u00b0. Ir spectra were reported.<\/p>\n

Zhurnal Organicheskoi Khimii published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Product Details of C16H12N2O2<\/a>.<\/p>\n

Referemce:
https:\/\/en.wikipedia.org\/wiki\/Pyrazole<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Zhurnal Organicheskoi Khimii published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Product Details of C16H12N2O2<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[740],"class_list":["post-11071","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-m-w250-300"],"yoast_head":"\nLapkin, I. I.'s team published research in Zhurnal Organicheskoi Khimii in 2 | CAS: 13599-22-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Lapkin, I. I. published the artcileEsters of oxo acids of acetylene series. VI. 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