{"id":11049,"date":"2022-11-17T05:43:14","date_gmt":"2022-11-16T21:43:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11049"},"modified":"2022-11-17T05:43:14","modified_gmt":"2022-11-16T21:43:14","slug":"zimmermann-dianes-team-published-research-in-tetrahedron-in-1998-08-06-cas-27412-71-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11049","title":{"rendered":"Zimmermann, Diane’s team published research in Tetrahedron in 1998-08-06 | CAS: 27412-71-1"},"content":{"rendered":"

Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles<\/i><\/b>, Quality Control of 27412-71-1<\/a>, the main research area is pyrazolol methyl preparation.<\/p>\n

2,3-Dihydropyrazolo[3,2-b]oxazoles were used as intermediates in a new method for preparation of 1-methyl-3-hydroxypyrazoles. Synthesis of this bicyclic system was achieved either by alkylation of 3-hydroxypyrazole with 1,2-dibromoethane or, with better yields, by cyclization of 1-tosyl-2-(2-hydroxyethyl)pyrazol-3-ones via a nitrogen to oxygen transfer of the tosyl group. Alkylation with Me trifluoromethanesulfonate followed by dihydrooxazole ring-opening with sodium iodide led to the 1-methyl-2-(2-iodoethyl)pyrazoles. Removal of the iodoethyl chain on N-2 to give the target 3-hydroxypyrazoles was achieved either via a cyanation and then a decyanoethylation reaction or via an elimination of hydrogen iodide, followed by an iodine-based oxidation of the resulting vinylic derivative Using the latter method, 1-methyl-3-hydroxypyrazoles were obtained in 58-73% yields from the corresponding 2,3-dihydropyrazolo[3,2-b]oxazoles.<\/p>\n

Tetrahedron published new progress about pyrazolol methyl preparation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Tetrahedron published new progress about pyrazolol methyl preparation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[678,131],"tags":[717],"class_list":["post-11049","post","type-post","status-publish","format-standard","hentry","category-27412-71-1","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nZimmermann, Diane's team published research in Tetrahedron in 1998-08-06 | CAS: 27412-71-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles, Quality Control of 27412-71-1, the main research area is pyrazolol methyl preparation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zimmermann, Diane's team published research in Tetrahedron in 1998-08-06 | CAS: 27412-71-1 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles, Quality Control of 27412-71-1, the main research area is pyrazolol methyl preparation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-16T21:43:14+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049\",\"name\":\"Zimmermann, Diane's team published research in Tetrahedron in 1998-08-06 | CAS: 27412-71-1 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-16T21:43:14+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles, Quality Control of 27412-71-1, the main research area is pyrazolol methyl preparation.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11049#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Zimmermann, Diane’s team published research in Tetrahedron in 1998-08-06 | CAS: 27412-71-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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